^(11)C-METPET/CT与MRI融合在脑胶质瘤术后放射治疗靶区定位中的应用

Application of ^(11)C-MET PET/CT and MRI fusion in target location of postoperative radiotherapy for glioma

目的:探讨^(11)C-蛋氨酸-PET/CT(^(11)C-METPET/CT)与核磁共振成像(MRI)融合在脑胶质瘤术后放射治疗靶区定位中的应用价值。方法:选取30例脑胶质瘤术后患者为研究对象。所有患者于术后两周内行MRI与^(11)C-METPET/CT检查,采用^(11)C-METPET/CT、^(11)C-METPET/CT与MRI融合法勾画靶区。比较两种方式勾画的肿瘤靶区体积(GTV)、临床靶区体积(CTV)及靶区重合度及不同医师勾画的靶区体积大小。结果:^(11)C-METPET/CT与MRI融合法勾画的GTV、CTV小于^(11)C-METPET/CT法(P<0.05)。两种方法勾画的GTV、CTV重合度差异有统计学意义(P<0.05)。不同医师采用^(11)C-METPET/CT与MRI融合法、^(11)C-METPET/CT法勾画的GTV、CTV比较,差异无统计学意义(P>0.05)。结论:^(11)C-METPET/CT与MRI融合勾画可以缩小脑胶质瘤术后放射治疗靶区,有较好的应用价值。

Objective:To investigate the application value of ^(11)C-methionine-PET/CT(^(11)C-MET PET/CT)and magnetic resonance imaging(MRI)fusion in the localization of radiotherapy target area after glioma surgery.Methods:A total of 30 patients with glioma were selected as the research objects.All patients underwent MRI and ^(11)C-MET PET/CT examination within 2 weeks after operation.The target areas were delineated by ^(11)C-MET PET/CT,^(11)C-MET PET/CT and MRI fusion methods.The gross tumor volume(GTV),clinical target volume(CTV)and target coincidence degree delineated by the two methods were compared.And the target volume delineated by different physicians were compared.Results:The GTV and CTV delineated by ^(11)C-MET PET/CT and MRI fusion method were significantly smaller than those by ^(11)C-MET PET/CT method(P<0.05).There was significant difference in the coincidence degree of GTV and CTV drawn by the two methods(P<0.05).There was no significant difference in GTV and CTV between different physicians using ^(11)C-MET PET/CT and MRI fusion method or ^(11)C-MET PET/CT method(P>0.05).Conclusion:^(11)C-MET PET/CT and MRI fusion mapping can reduce the target area of postoperative radiotherapy for glioma,which has high application value.