摘要
中药谱效关系能揭示中药多靶点多成分协同作用。指纹图谱是建立在化学成分研究基础上的一种鉴定手段。现已涉及多种分析方法,包括高/超效液相色谱法(H/UPLC)、气相色谱法(GC)、质谱法(MS)等。谱效关系在指纹图谱研究基础上,通过数据分析处理技术与药效联系起来,进一步明确发挥药效的具体活性成分。本研究主要对指纹图谱、谱效关系的研究进展进行了综述,为后续谱效关系的研究与发展提供参考。
Spectrum-effect relationship could reveal the synergistic effect of multi-target and multi-component of traditional Chinese medicine. Fingerprinting is an identification tool based on chemical composition research which was developed. Various analytical methods have been involved, including high performance liquid chromatography(HPLC), gas chromatography(GC), mass spectrometry(MS), etc. Spectrum-effect relationship based on the fingerprinting study, combines data analysis and processing techniques with the efficacy of the drug, so as to further clarify the specific active ingredients that exert the efficacy. In this paper, we mainly reviewed fingerprinting, spectrum-effect relationships, and provide references for future research and development of spectrum-effect relationships.
作者
王琳琳
牛晨冬
卢宜然
李宗锴
张金玲
刘吉成
孙宇
刘雷
刘琦
马玉坤
郭丽娜
Wang Linlin;Niu Chendong;Lu Yiran;Li Zongkai;Zhang Jinling;Liu Jicheng;Sun Yu;Liu Lei;Liu Qi;Ma Yukun;Guo Lina(School of pharmacy,Qiqihar Medical University,Qiqihar,Heilongjiang,161006,China;Institute of medical sciences,Qiqihar Medical University,Qiqihar,Heilongjiang,161006,China)
出处
《齐齐哈尔医学院学报》
2022年第4期379-383,共5页
Journal of Qiqihar Medical University
基金
黑龙江省自然基金项目(LJ2019H126)。
关键词
指纹图谱
谱效关系
研究进展
Fingerprint
Spectrum-effect relationship
Research Progress