摘要
The recent development of tough tissue adhesives has stimulated intense interests among material scientists and medical doctors.However,these adhesives have seldom been tested in clinically demanding surgeries.Here we demonstrate adhesive anastomosis in organ transplantation.Anastomosis is commonly conducted by dense sutures and takes a long time,during which all the vessels are occluded.Prolonged occlusion may damage organs and even cause death.We formulate a tough,biocompatible,bioabsorbable adhesive that can sustain tissue tension and pressurized flow.We expose the endothelial surface of vessels onto a gasket,press two endothelial surfaces to the adhesive using a pair of magnetic rings,and reopen the bloodstream immediately.The time for adhesive anastomosis is shortened compared to the time for sutured anastomosis.We have achieved adhesive anastomosis of a great vein in transplanting the liver of a pig.After the surgery,the adhesive is absorbed,the vein heals,and the pig lives for over one month.
基金
This work was supported by grants from the Key R&D Project of Shaanxi Province(No.2020GXLH-Z-001)
the National Key R&D Project of China(No.2018YFC0115300 and No.2018YFC0115305)
the National Natural Science Foundation of China(No.81727802,12172272,11702208,11820101001)
China Postdoctoral Science Foundation(No.BX201700192,2018M643620).
