摘要
Both inflammation and anti-inflammation are involved in the protection of retinal cells.Antagonists of the hypothalamic growth hormone-releasing hormone receptor(GHRHR)have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs,some with systemic complications.Such effects are also found in ocular inflammatory and neurologic injury studies.In experimental models of mice and rats,both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental conditions.This review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.
基金
supported by the National Natural Science Foundation of China(81570849 to LPC)
Joint Regional Basic Science and Applied Basic Science Research Fund of Guangdong Province(2019 A1515110685 to TKN)
Special Fund for Chinese Medicine Development of Guangdong Province(20202089 to TKN)
the Natural Science Foundation of Guangdong Province(2020 A1515010415 to LPC)
an internal grant from Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
Grant for Key Disciplinary Project of Clinical Medicine under the Guangdong High-level University Development Program, China
The Chinese University of Hong Kong Direct Grant(2020.067 to WKC)
