非布司他对痛风病人三酰甘油水平的影响

EFFECT OF FEBUXOSTAT ON TRIGLYCERIDE LEVEL IN PATIENTS WITH GOUT

目的 观察非布司他对原发性痛风病人三酰甘油(TG)水平的影响。方法 选取2016年9月—2020年9月在青岛大学附属医院痛风专病门诊就诊的病人298例,分析非布司他治疗期间TG水平变化。结果 治疗2~4周、6~8周时的TG水平均较治疗前明显升高(t=4.294、7.760,P<0.01),治疗10~12周时的TG水平与治疗前比较变化不明显。根据治疗前TG水平分组,TG<1.7 mmol/L组治疗2~4周、6~8周时的TG水平均较治疗前明显升高(Z=4.099、6.814,P<0.01),治疗10~12周时的TG水平与治疗前比较变化不明显;1.7 mmol/L≤TG<2.3 mmol/L组治疗2~4周时的TG水平较治疗前明显升高(Z=3.794,P<0.01),治疗6~8周、10~12周时的TG水平与治疗前比较变化不明显。结论 非布司他治疗早期会引起痛风病人TG水平升高。

Objective To investigate the effect of febuxostat on triglyceride(TG) level in patients with primary gout. Methods A total of 298 patients with gout who attended the outpatient service of gout in The Affiliated Hospital of Qingdao University from September 2016 to September 2020 were enrolled, and the change in TG level was observed during febuxostat treatment. Results There was a significant increase in TG level at weeks 2-4 and 6-8 of treatment(t=4.294,7.760;P<0.01), and TG level at weeks 10-12 of treatment was similar to that before treatment. The patients were divided into TG <1.7 mmol/L group and 1.7 mmol/L ≤TG <2.3 mmol/L group according to TG level before treatment. The TG <1.7 mmol/L group had a significant increase in TG level at weeks 2-4 and 6-8 of treatment(Z=4.099,6.814;P<0.01), while TG level at weeks 10-12 of treatment was similar to that before treatment;the 1.7 mmol/L ≤TG <2.3 mmol/L group had a significant increase in TG level at weeks 2-4 of treatment(Z=3.794,P<0.01), while TG level at weeks 6-8 and 10-12 of treatment was similar to that before treatment. Conclusion There is an increase in TG level in patients with gout in the early stage of febuxostat treatment.