婚姻状况和阿尔茨海默病脑脊液生物标志物的相关性

ASSOCIATION BETWEEN MARITAL STATUS AND CEREBROSPINAL FLUID BIOMARKERS FOR ALZHEIMER’S DISEASE

目的 探讨中国北方汉族认知正常人群婚姻状况与阿尔茨海默病(AD)脑脊液(CSF)生物标志物之间的关系。方法 从中国人AD生物标志物与生活方式研究(CABLE)数据库中选取998名认知正常参与者作为研究对象,在校正了年龄、性别、教育程度年限、中国改良版简易智力状态检查量表(CM-MMSE)评分和载脂蛋白E?4(APOE?4)携带状态后,采用多元线性回归模型对婚姻与AD CSF生物标志物β-淀粉样蛋白42(Aβ42)、β-淀粉样蛋白40(Aβ40)、总tau蛋白(t-tau)以及磷酸化tau蛋白(p-tau)的关系进行研究。结果 多元线性回归结果表明,婚姻状况与Aβ42水平(β=-9.118,P=0.102)、Aβ40水平(β=0.001,P=0.999)、t-tau水平(β=1.657,P=0.997)和p-tau水平(β=0.113,P=0.840)以及生物标志物比值Aβ42/Aβ40(β=-1.592,P=0.647)、p-tau/Aβ42(β=12.970,P=0.634)、t-tau/Aβ42(β=28.125,P=0.785)均不存在显著相关性。按年龄、性别进行亚组分析也得到同样的结果。结论 对于认知正常人群,婚姻状态对AD CSF生物标志物没有显著的影响。

Objective To investigate the association between marital status and cerebrospinal fluid(CSF) biomarkers for Alzheimer’s disease(AD) in cognitively intact individuals in northern Han Chinese. Methods A total of 998 cognitively intact individuals were selected from the Chinese Alzheimer’s Biomarker and LifestylE(CABLE) as subjects, and after adjustment for age, sex, educational background, Chinese-modified Mini-Mental State Examination score, and apolipoprotein ε4 status, the multiple linear regression model was used to assess the association of marital status with the CSF biomarkers for AD including β-amyloid 42(Aβ42), β-amyloid 40(Aβ40), total tau(t-tau), and phosphorylated tau(p-tau). Results The multiple linear regression analysis showed that marital status was not significantly associated with Aβ42(β=-9.118,P=0.102), Aβ40(β=0.001,P=0.999), t-tau(β=1.657,P=0.997), p-tau(β=0.113,P=0.840), and biomarker ratios including Aβ42/Aβ40(β=-1.592,P=0.647), p-tau/Aβ42(β=12.970,P=0.634), and t-tau/Aβ42(β=28.125,P=0.785). The same results were obtained from the subgroup analysis based on age and sex. Conclusion Marital status has no significant influence on the CSF biomarkers for AD in cognitively intact individuals.