摘要
Naproxen–β-cyclodextrin inclusion complex was prepared by the freeze-drying method and analyzed by IR,UV spectroscopy,X-ray diffractometry and differential scanning calorimetry.Phase solubility,dissolution and inclusion rate of the complex were determined.The phase solubility diagram was of the AL type,which revealed that the molar ratio of naproxen toβ-cyclodextrin was 1:1.The solubility of naproxen significantly increased with increasingβ-cyclodextrin concentration.The apparent stability constant,Kc,was calculated from the slope and intercept of the AL solubility diagram as 2376/M.The total released amount and released time of naproxen from the inclusion complex were better than that of the intact naproxen.
基金
the Guangdong Province Science and Technology Program Foundation(No.2013B040200029)
2016 National Drug Evaluation Special Foundation of China and the National Natural Science Foundation of China(21375027,21335002,and 21427806).
