老年糖代谢异常人群慢性肾脏病患病情况研究

Prevalence of Chronic Kidney Disease in Elderly Patients with Abnormal Glucose Metabolism

目的:研究≥60岁的2型糖尿病人群和糖耐量受损人群慢性肾脏病患病情况,并探讨其危险因素,为慢性肾脏病早期防控提供参考。方法:采用问卷调查、体格检查和实验检查,比较2型糖尿病人群、糖耐量受损人群和血糖正常人群间因子差异,利用多因素logistic回归分析模型分析慢性肾脏病的发病因素。结果:1621名调查对象中,共检出血糖正常人群1102人(67.98%)、糖耐量受损人群249人(15.36%)和2型糖尿病人群270人(16.66%),其中2型糖尿病人群(27.41%)和糖耐量受损人群(20.88%)的慢性肾脏病患病率高于血糖正常人群(10.71%)。多因素logistic回归分析结果显示,糖耐量受损和2型糖尿病均是慢性肾脏病发病的独立影响因素。结论:应对≥60岁的2型糖尿病人群及糖耐量受损人群合并高血压、血脂异常、高尿酸及肥胖者强化危险因素干预和管理。

OBJECTIVE To investigate the prevalence of chronic kidney disease(CKD)in patients aged 60 years and over with type 2 diabetes mellitus(T2 DM)and impaired glucose tolerance(IGR),and to explore the risk factors of CKD,then to provide reference for early prevention and control of CKD.METHODS 1621 registered residence residents over 60 years old who live in Shanghai Jinshan Industrial Zone were investigated in the study.The survey included the basic information,history,lifestyle,physical examination and laboratory examination.Then compared different factors between three groups.The risk factors of CKD were analyzed by Logistic regression model.RESULTS Among the 1621 respondents,a total of 1102(67.98%)with normal glucose tolerance,249(15.36%)and 270 with type 2 diabetes(16.66%)were detected,among which the prevalence of chronic kidney disease in type 2 diabetes(27.41%)and impaired glucose tolerance(20.88%)were higher than normal glycemic patients(10.71%).The results of the multivariate logistic regression analysis showed that both impaired glucose tolerance and type2 diabetes were independent influencing factors in the onset of chronic kidney disease.CONCLUSION The intervention of risk factors should be strengthened in patients with diabetes and impaired glucose tolerance(IGT)over 60 years old complicated with hypertension,dyslipidemia,hyperuricemia and obesity.