不同质子泵抑制剂的药理特点及临床应用分析

Analysis of the Pharmacological Characteristics and Clinical Application of Different Proton Pump Inhibitors

目的对不同质子泵抑制剂的药理特点及临床应用价值进行探析。方法选取2020年1月—2021年6月该院接收的104例消化性溃疡患者为研究对象,按数字表法分组,将52例接受泮托拉唑治疗的患者选为对照组,将52例接受奥美拉唑治疗的患者选为观察组,对比患者症状评分,统计总有效率、Hp根除率、3 d缓解率、复发率及不良反应发生率。结果治疗后,观察组患者胃胀、恶心呕吐、上腹疼痛、反酸症状评分分别为(0.35±0.19)分、(0.42±0.24)分、(0.46±0.25)分、(0.53±0.14)分,明显优于对照组,差异有统计学意义(P<0.05)。观察组疗效总有效率为90.38%,明显高于对照组,差异有统计学意义(χ^(2)=4.300,P<0.05)。治疗后,观察组患者Hp根除率(82.69%)、3 d症状缓解率(86.54%)、复发率(9.62%),均优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组发生失眠、头痛、皮疹、便秘等不良反应共7例,发生率为13.46%,明显少于对照组,差异有统计学意义(χ^(2)=4.522,P<0.05)。结论各类质子泵抑制剂在消化性溃疡疾病治疗中均发挥出其治疗优势,但出于患者安全考虑,应充分关注患者用药后不良反应,尽量选择不良反应少、症状缓解效果好的药物。

Objective To analyze the pharmacological characteristics and clinical application value of different proton pump inhibitors.Methods 104 patients with peptic ulcer received in the hospital from January 2020 to June 2021 were selected as the research object.They were grouped according to the digital table method.52 patients treated with pantoprazole were selected as the control group and 52 patients treated with omeprazole were selected as the observation group.The symptom scores of patients were compared and the total effective rate,Hp eradication rate,3 d remission rate,recurrence rate and incidence of adverse reactions were counted.Results After treatment,the patients in the observation group had gastric distention,nausea and vomiting,upper abdominal pain scores of acid reflux symptoms were(0.35±0.19)points,(0.42±0.24)points,(0.46±0.25)points,(0.53±0.14)points,respectively,which were significantly better than the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 90.38%,which was significantly higher than that of the control group,and the difference was statistically significant(χ^(2)=4.300,P<0.05).After treatment,the Hp eradication rate of the observation group was(82.69%),3 d symptom relief rate(86.54%)and recurrence rate(9.62%)were better than those in the control group,and the difference was statistically significant(P<0.05).After treatment,there were 7 cases of adverse reactions such as insomnia,headache,rash and constipation in the observation group,and the incidence was 13.46%,which was significantly lower than that in the control group,and the difference was statistically significant(χ^(2)=4.522,P<0.05).Conclusion All kinds of proton pump inhibitors have exerted their therapeutic advantages in the treatment of peptic ulcer disease.However,due to patient safety considerations,patients should be fully concerned about the adverse reactions after medication,and try to choose drugs with fewer side effects and good symptom relief.