手性拆分技术在药物研发中的研究进展及应用

Research Progress and Application of Chiral Resolution Technology in Drug Research and Development

手性药物是指药物分子具有对映异构体的一类药物,其不同的异构体在生物体内可能有不同作用。相比于消旋体,手性对映体药物有更高活性和更小的毒副作用,因此,如何获得高纯度手性单体备受关注。介绍了几种经典手性物质拆分法,包括结晶拆分法、生物拆分法、化学拆分法、色谱拆分法、毛细管电泳法、膜分离法,梳理了各类方法优缺点并对手性拆分技术未来发展方向进行了展望。

Chiral drugs refer to a class of drugs whose drug molecules have enantiomers. Different isomers may have different effects in organisms. Compared with racemates, chiral enantiomers have higher activity and less toxic and side effects.Therefore, how to obtain high-purity chiral monomers has attracted much attention. This paper introduces several classical chiral resolution methods, including crystal resolution, biological resolution, chemical resolution, chromatographic resolution, capillary electrophoresis and membrane separation, and combs the advantages, disadvantages and future prospects of various methods.