注射用烟酸致静脉炎不良反应2例

Two cases of adverse reaction of phlebitis caused by niacin for injection

目的探讨注射用烟酸致静脉炎的原因及治疗措施,为临床安全用药提供参考。方法对2例年龄>65岁的冠心病患者静滴注射用烟酸致药物性静脉炎进行回顾性分析。结果2例患者在输注注射用烟酸过程中出现药物性静脉炎后首先停药,并给予50%硫酸镁湿敷对症治疗,经过及时处理,2例患者均好转。结论注射用烟酸可引起静脉炎,常表现为红肿型、栓塞型,可能与注射用烟酸中辅料成分甘露醇、pH值偏酸性及患者年龄偏大导致血管条件变差有关。临床应警惕不良反应的发生并积极应对,可采用停药并予硫酸镁外敷对症治疗。

Objective To explore the causes and treatment of phlebitis caused by niacin for injection,and to provide reference for the safe use of drugs.Methods A retrospective analysis was performed in two patients over 65-year-old with coronary heart disease and drug-induced phlebitis caused by intravenous injection of niacin.Results Drug-induced phlebitis occurred in two patients during the process of infusion of niacin for injection,which required timely treatment.Symptomatic treatment of wet dressing of 50%magnesium sulphate was given after withdrawal of the drug.After timely treatment,the symptoms of two patients were improved.Conclusion Niacin for injection can cause phlebitis in clinical drug treatment.It is often characterized by redness,swelling and embolism,which may be related to factors such as mannitol,drug pH<7 and poor vascular conditions in elderly patients.Clinical attention should be paid to discovering and treating the adverse reactions,and it is necessary to stop the drug timely and give symptomatic treatment of wet dressing of magnesium sulphate.