乳果糖联合莫沙必利治疗老年慢性功能性便秘的疗效及安全性

Efficacy and safety of lactulose combined with mosapride in the treatment of senile chronic functional constipation

目的:分析乳果糖联合莫沙必利对老年慢性功能性便秘患者首次排便时间、排便频率及对安全性的影响。方法:选取山西省运城市中心医院2020年1月-2021年6月收治的120例老年慢性功能性便秘患者,按照随机数字表法分为观察者和对照组,每组60例。对照组使用乳果糖口服溶液治疗,观察组使用乳果糖联合莫沙必利治疗。观察并比较2组首次排便时间分布、排便频率及安全性指标。结果:观察组首次排便时间分布显著优于对照组(P<0.05);2组治疗后排便频率均显著提高,且组间差异有统计学意义(P<0.01);观察组首次排便性状分型显著优于对照组(P<0.05);2组不良反应总发生率差异无统计学意义(P>0.05)。结论:乳果糖联合莫沙必利应用于老年慢性功能性便秘患者,能够显著提前首次排便时间、提高排便频率、优化首次排便性状分型,不良反应低,安全性高,值得临床推广应用。

Objective: To analyze the effect of lactulose combined with mosapride on the first defecation time, defecation frequency and safety in elderly patients with chronic functional constipation. Methods: A total of 120 elderly patients with chronic functional constipation admitted to our hospital from January 2020 to June 2021 were selected and divided into two groups according to random number table method, with 60 cases in each group. The control group was treated with lactulose oral solution, and the observation group was treated with lactulose combined with mosapride. The time distribution of the first defecation, the frequency of defecation and the safety data were observed and compared between the two groups. Results: The distribution of the first defecation time in the observation group was significantly better than that in the control group(P<0.05);The frequency of defecation in both groups after treatment was significantly increased, and the difference between the groups was significant(P<0.01);The first defecation trait classification in the observation group was significantly better than that in the control group(P<0.05);There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion: Lactulose combined with mosapride in elderly patients with chronic functional constipation can significantly advance the time of first defecation, increase the frequency of defecation, and optimize the classification of first defecation traits, with low adverse reactions and high safety, which is worthy of clinical application.