盐酸达泊西汀治疗早泄对患者精子质量及心理应激的影响研究

Effect of Dapoxetine Hydrochloride on Sperm Quality and Psychological Stress in Patients with Premature Ejaculation

目的探讨盐酸达泊西汀治疗早泄对患者精子质量及心理应激的影响研究。方法选取2018年6月~2021年6月山西白求恩医院收治的190例早泄患者作为研究对象,以随机数表法分为对照组(95例)和观察组(95例)。对照组给予盐酸舍曲林片,观察组给予盐酸达泊西汀片,两组均持续治疗2个月。对比治疗前、治疗2个月后两组焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、平均阴道内射精潜伏期(IELT)、早泄量表各项评分及精液相关指标。结果与治疗前相比,治疗2个月后,两组SAS及SDS评分降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗2个月后,两组IELT高于治疗前、治疗1个月后,治疗1个月后高于治疗前,且治疗2个月后观察组IELT高于对照组,差异有统计学意义(P<0.05)。与治疗前相比,治疗2个月后,两组性生活满意度、射精控制能力、伴侣间沟通困难、早泄相关负性情绪评分升高,且观察组高于对照组,差异有统计学意义(P<0.05)。与治疗前相比,治疗2个月后,两组精子总数、精子密度、前向运动精子百分率比较差异均无统计学意义,且组间比较差异无统计学意义(P>0.05)。结论盐酸舍曲林与盐酸达泊西汀均可改善早泄患者精子质量,但盐酸达泊西汀可减轻患者心理应激,提高患者射精控制能力,进而有助于改善患者性生活质量。

Objective To study the effect of dapoxetine hydrochloride on sperm quality and psychological stress in patients with premature ejaculation.Methods One hundred and ninety patients with premature ejaculation admitted to Bethune Hospital in Shanxi Province from June 2018 to June 2021 were selected as the research objects,and were randomly divided into control group(95 cases)and observation group(95 cases).The control group was given sertraline hydrochloride tablets,and the observation group was given dapoxetine hydrochloride tablets.Both groups were treated continuously for 2 months.The scores of self-rating anxiety scale(SAS),self-rating depression scale(SDS),Intra-vaginal ejaculation latency time(IELT),scores of premature ejaculation scale and semen related indexes were compared before treatment and two months after treatment.Results After 2 months of treatment,the scores of SAS and SDS in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).After 2 months of treatment,IELT in the two groups was higher than that before treatment,after 1 month of treatment,after 1 month of treatment,and after 2 months of treatment,IELT in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After 2 months of treatment,the scores of sexual satisfaction,ejaculation control ability,communication difficulty between partners and negative emotion related to premature ejaculation in the two groups were higher than those before treatment,and the scores in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).Compared with before treatment,after 2 months of treatment,there was no significant difference in total sperm count,sperm density and percentage of forward motility sperm between the two groups(P>0.05).Conclusion Sertraline hydrochloride and dapoxetine hydrochloride can improve sperm quality in patients with premature ejaculation,but dapoxetine hydrochloride can alleviate psychological stress and improve ejaculation control ability,which is helpful to improve sexual life quality of patients.