胺碘酮联合琥珀酸美托洛尔缓释片治疗对快速心律失常患者血压和心率的影响

Effect of Amiodarone Combined with Metoprolol Succinate Sustained Release Tablets on Blood Pressure and Heart Rate in Patients with Tachyarrhythmia

目的探讨对快速心律失常患者采用胺碘酮联合琥珀酸美托洛尔缓释片治疗的临床效果及对患者血压、心率的影响。方法便利选择医院2020年1—12月收治快速心律失常患者80例,按照随机数表法分为对照组(常规口服美托洛尔缓释片治疗,n=40)与研究组(联合使用胺碘酮治疗,n=40),比较两组临床疗效,检测两组患者治疗前后的血压、心率水平,并评估两组患者左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD),分析对患者心功能的影响。结果研究组治疗总有效率92.50%,高于对照组72.50%,差异有统计学意义(χ^(2)=5.541,P<0.05)。治疗后研究组收缩压、舒张压、心率水平分别为(125.81±10.30)mmHg、(80.35±9.64)mmHg、(91.45±10.28)次/min,均小于对照组;治疗后研究组LVEF、LVESD、LVEDD水平分别为(64.52±4.17)%、(38.65±3.54)mm、(48.07±3.85)mm,均优于对照组,差异有统计学意义(t=2.780、3.113、4.186、4.619、3.219、3.403,P<0.05)。结论对快速心律失常患者在美托洛尔缓释片治疗基础上联合使用胺碘酮能够提高治疗效果,可改善血压、心率水平,有利于改善患者心功能,值得推广。

Objective To explore the clinical effect of amiodarone combined with metoprolol succinate sustained-release tablets in the treatment of patients with tachyarrhythmia and the effect on the blood pressure and heart rate of the patients.Methods Conveniently selected hospitals to treat 80 patients with tachyarrhythmia from January to December 2020.According to the random number table,they were divided into control group(conventional oral metoprolol sustained-release tablet treatment,n=40)and study group(combined with amiodarone treatment,n=40).The clinical effects of the two groups were compared,and the blood pressure and heart rate levels of the two groups of patients before and after treatment were measured.The left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),and left ventricular end-diastolic diameter(LVEDD)were evaluated in the two groups,and their effects on cardiac function were analyzed.Results The total effective rate of treatment in the study group was 92.50%,which was higher than 72.50% in the control group,and the difference was statistically significant(χ^(2)=5.541,P<0.05).After treatment,the systolic blood pressure,diastolic blood pressure,and heart rate levels of thestudy group were(125.81±10.30)mmHg,(80.35±9.64)mmHg,and(91.45±10.28)beats/min,which were all lower than those of the control group;after treatment,the levels of LVEF,LVESD,and LVEDD in the study group were(64.52±4.17)%,(38.65±3.54)mm,and(48.07±3.85)mm,respectively,which were better than those of the control group,the difference was statistically significant(t=2.780,3.113,4.186,4.619,3.219,3.403,P<0.05).Conclusion For patients with tachyarrhythmia,the combined use of amiodarone on the basis of the treatment of metoprolol sustained-release tablets can improve the therapeutic effect.It can improve blood pressure and heart rate levels,and is beneficial to improve the heart function of patients.It is worthy of promotion.