厚朴及其有效成分的中枢抑制作用及机制的研究进展

Research Progress in Central Inhibitory Effect and Mechanism of Magnoliae Officinalis Cortex and Its Active Ingredients

厚朴及其有效成分具有镇静催眠、抗焦虑、抗癫痫和解热镇痛的作用。厚朴酚与和厚朴酚主要是通过增强γ-氨基丁酸(γ-aminobutyric acid,GABA)与其受体的结合,促进GABA的生物合成,提高GABA含量,发挥中枢抑制作用;也可通过促进β-内啡肽的释放和激动大麻素受体-1,对抗中枢兴奋性神经递质谷氨酸和N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)的兴奋作用,以及抑制神经细胞的Na^(+)电流、5-羟色胺的释放和前列腺素的生物合成,产生其中枢抑制和解热镇痛作用。笔者综述了厚朴及其有效成分的中枢抑制作用及机制,并对其研究进展做了分析。

Magnoliae Officinalis Cortex and its active ingredients have sedation,hypnotism,anxiolytic and antiepileptic effects,and antipyretic and analgesic effects.Magnolol and honokiol express central inhibition,and antipyretic and analgesic effects chiefly by increasingγ-aminobutyric acid(GABA)binding to its receptor,and enhancing biosynthesis and content of GABA,then by improving the release of β-endorphin,and activating cannabine receptor-1to antagonize the effects of the excitative neurotransmitter,glutamic acid and N-methyl-D-aspartate(NMDA),and inhibiting biosynthesis of prostaglandin,the release of 5-TH and Na^(+)current of neural cells.In this paper,the literature on the central inhibition and mechanism of Magnolia Officinalis Cortex and its active components are reviewed,and the research progress is also analyzed.