睫状体淋巴瘤临床诊疗研究进展

Progress in diagnosis and treatment of ciliary body lymphoma

睫状体淋巴瘤是极为罕见的眼内淋巴瘤,可分为原发性和继发性,常见病理类型为黏膜相关淋巴组织结外边缘区B细胞淋巴瘤及弥漫大B细胞淋巴瘤,T细胞淋巴瘤较为少见。睫状体淋巴瘤的临床表现与前葡萄膜炎相似,病情进展可出现前房积脓和继发性青光眼,特征性表现包括虹膜结节、虹膜新生血管及前房积血。超声生物显微镜检查可见睫状体淋巴瘤细胞弥漫性浸润或占位。细胞学或组织病理学检查是其诊断的金标准,免疫细胞化学分析、流式细胞学分析、细胞因子检测及基因重排可提高其诊断率。放射治疗、化学疗法或二者联合治疗通常可获得较好预后。本文对睫状体淋巴瘤的分类及病理类型、眼部表现及检查、诊断及治疗进行综述,以期为临床工作提供参考。

Intraocular lymphoma with ciliary body involvement is extremely rare,which can be divided into primary and secondary types.The common pathological patterns are mucosa-associated lymphoid tissue B-cell lymphoma and diffuse large B-cell lymphoma,and T-cell lymphoma is relatively rare.The clinical manifestations of ciliary body lymphoma are similar to anterior uveitis.Hypopyon and secondary glaucoma can result from the disease,and the differentiating features include iris patches,iris neovascularization,and hyphema.Diffuse infiltration or space-occupying lesions of ciliary body lymphoma can be found by ultrasound biomicroscopy.Cytological and/or histopathological examination is the gold standard for its diagnosis.Immunohistochemistry,flow cytometry,cytokine analysis,and gene rearrangement are often used in combination to improve the diagnosis rate.Radiotherapy,chemotherapy,or combination therapy can achieve a better prognosis.This paper reviewed classification,pathological types,ocular manifestations,examinations,diagnosis,and treatment of ciliary body lymphoma to provide a reference for clinical practice.