精神分裂症患者及未患病一级亲属的脑功能网络度中心性研究

Study on the degree centrality of brain functional network in schizophrenia and unaffected first-degree relatives

目的探讨静息状态下精神分裂症患者及未患病一级亲属脑功能网络节点重要性的改变情况。方法对2016年10月至2019年6月新疆医科大学第一附属医院收治的26例精神分裂症患者(精神分裂症组)及同期招募的21名未患病的一级亲属(亲属组)、22名健康对照者(对照组)进行静息态功能磁共振图像(rs-fMRI)采集,使用阳性和阴性症状量表(PANSS)评估症状,利用基于体素的度中心性(DC)方法分析rs-fMRI数据,采用方差分析比较3组间DC值的差异,并分析差异脑区的DC值与精神分裂症患者病程和病理特征之间的相关性。结果与对照组比较,精神分裂症组及亲属组左侧杏仁核和右侧额上回的DC值比较,差异有统计学意义(F=16.433、12.218;P<0.01),其中精神分裂症组及亲属组的左侧杏仁核的DC值低于对照组,右侧额上回的DC值高于对照组,差异有统计学意义(P<0.05)。精神分裂症组患者多个脑区的DC值和病程及PANSS评分相关(P<0.01)。结论精神分裂症患者及未患病的一级亲属静息状态下左侧杏仁核和右侧额上回的DC值存在差异,提示精神分裂症及亲属的脑网络存在局部连接异常。

Objective To investigate the changes in the importance of brain function network nodes in schizophrenic patients and unaffected first degree relatives under resting state.Methods The resting-state functional magnetic resonance imaging(rs-fMRI)were collected from 26 schizophrenia patients(schizophrenia group)admitted to the First Affiliated Hospital of Xinjiang Medical University from October 2016 to June 2019,21 unaffected first-degree relatives(schizophrenia relatives group)and 22 healthy controls(normal control group)recruited during the same period.Symptoms were assessed using the Positive and Negative Symptom Scale(PANSS).The voxel-based degree centrality(DC)method was utilized to analyze the rs-fMRI data,and the variance analysis was used to compare the differences of DC values among the three groups.Finally,the correlation between the DC values in the different brain regions and the course and pathological characteristics of schizophrenia patients were analyzed.Results Compared with the healthy control group,there was significant difference in DC values of left amygdala and right superior frontal gyrus in schizophrenia group and relative group(F=16.433,12.218;P<0.01).The DC value of the left amygdala in schizophrenia group and relative group was lower than that in the control group,and the DC value of the right superior frontal gyrus was higher than that in the control group,the difference was statistically significant(P<0.05).In addition,the DC value of multiple brain regions is related to the course of the disease and the PANSS score of the schizophrenia group(P<0.01).Conclusions There are differences in the DC values of the left amygdala and the right superior frontal gyrus in schizophrenic patients and their unaffected first-degree relatives under resting state,suggesting that there were abnormal local connections in the brain network between the schizophrenia group and the relatives.