甘遂化学成分、药理活性和临床应用研究进展

Research progress on chemical constituents,pharmacological activities and clinical application of Euphorbia kansui

甘遂是大戟科大戟属植物甘遂(Euphorbia kansui T.N.Liou ex T.P.Wang)的干燥块根,是我国特有的中草药。甘遂中的主要化学成分为假白榄烷型二萜和巨大戟烷型二萜、大戟烷型和甘遂烷型三萜,具有抗肿瘤、抗病毒、抗炎、杀虫、抗氧化、抑制免疫系统等多种药理活性。该综述全面总结了102个萜类化合物和14个甾类化合物等化学成分及其结构特征,并对甘遂的药理活性、炮制和临床应用进行了系统的总结,以期为甘遂的临床合理用药、质量控制、资源综合利用及开发做参考。

The dry root tuber of Euphorbia kansui T.N.Liou ex T.P.Wang(Euphorbia genus in Euphorbiaceae) is a unique Chinese herbal medicine in China.The main chemical constituents and active components of E.kansui are jatrophane diterpenes,ingenane diterpenes,euphane triterpenes and tirucallane triterpenes,which have many pharmacological activities such as anti-tumor,anti-virus,anti-inflammatory,insecticidal,antioxidant and immune system inhibition.This review comprehensively summarized 102 terpenes and 14 steroids and their structural characteristics,and systematically summarized the pharmacological activity,processing and clinical application of E.kansui,in order to provide reference for clinical rational drug use,quality control,resource comprehensive utilization and development of E.kansui.