中药调节肠道菌群防治慢性心力衰竭的研究概述

A Review of Studies on the Regulation of Intestinal Flora and Prevention of Chronic Heart Failure with Traditional Chinese Medicine

总结中药以肠道菌群为靶点治疗疾病的机制与优势,并着重阐述中药调节肠道群防治慢性心力衰竭的机制。中药以肠道菌群为靶点治疗疾病的机制包括改善肠道微环境、纠正肠道菌群失调状态、调节肠道菌群代谢等,优势为多渠道、多靶点和整体调节。中药调节肠道菌群防治慢性心力衰竭的机制包括:增加有益菌相对丰度,降低致病菌相对丰度,改善肠道菌群的组成,维持肠道屏障功能,以及调节短链脂肪酸、胆汁酸、氧化三甲胺等心血管相关活性物质的代谢等。中药通过调节肠道菌群可达到减轻心肌炎症反应,逆转心室重构,改善心功能,缓解临床症状,延缓慢性心力衰竭进展的作用。

This paper summarizes the mechanisms and advantages of traditional Chinese medicine targeting intestinal flora to treat diseases and focuses on the mechanism of Chinese medicine regulating intestinal flora to prevent and treat chronic heart failure. Mechanisms include improving the intestinal microenvironment, correcting the dysregulation of intestinal flora and regulating the metabolism of intestinal flora. Advantages are multi-channel,multi-target and overall regulation. The mechanism of traditional Chinese medicine on regulating the intestinal flora to prevent and treat chronic heart failure includes increasing the relative abundance of beneficial bacteria,reducing the relative abundance of pathogenic bacteria, improving the composition of intestinal flora, maintaining intestinal barrier function and regulating the metabolism of cardiovascular-related active substances, such as short-chain fatty acids, bile acids and trimethylamine oxide. Thus, it can play a pharmacological effect in reducing myocardial inflammatory response, reverse ventricular remodeling, improve cardiac function, effectively relieve clinical symptoms and delay the progression of chronic heart failure.