肠道微生物组在炎症性肠病发病机制和治疗中的作用研究进展

Advances in gut microbiota in the pathogenesis and treatment of inflammatory bowel disease

肠道微生物组在人体健康中起着至关重要的作用。炎症性肠病(inflammatory bowel disease,IBD)是一种由多种环境因素(包括肠道微生物组)在遗传易感个体中引起的免疫疾病。尽管大多数研究表明肠道微生物组及其代谢物通过诱导炎症和免疫紊乱在肠道疾病的发生和发展中发挥作用,但仍无法确定微生物组与IBD发病机制之间的因果关系。该文总结了IBD发病过程中细菌、真菌和病毒微生物组的改变以及潜在的功能途径,探讨当前针对微生物组的治疗方法和前景。

The gut microbiota plays a critical role in human health.Inflammatory bowel disease(IBD)is an immunological disease caused by various environmental factors,including the gut microbiota,in genetically susceptible individuals.Although most studies have indicated the role of gut microbiota and their metabolites in contribution to the occurrence and development of intestinal diseases by inducing inflammation and immune disorders.However,the causal relationship between microbiota and IBD pathogenesis cannot be determined.In this review,the alteration of bacterial,fungal and viral microbiota and the potential functional pathways during IBD pathogenesis are summarized.Besides,the current therapeutic approaches targeting microbiota and the promising perspectives are introduced.