以肠道菌群为靶点的新型辅助降压模式研究进展

New Research Progress of a New Auxiliary Antihypertensive Model Targeting Intestinal Flora

肠道菌群是人体内环境的重要组成部分,参与和调节机体的免疫炎性反应和代谢过程,与高血压的发生、发展存在密切联系,在高血压疾病的研究中已成为焦点。本文总结了肠道菌群与高血压的关系,从炎症和免疫反应、脑-肠-骨髓轴、代谢物等方面阐明肠道菌群对高血压的影响及可能机制,重点从盐、益生菌、多酚类有机化合物三方面探讨饮食干预影响肠道菌群、改善血压的新型辅助降压途径,以期以肠道菌群为靶点,使通过饮食、中草药防治高血压的研究越来越深入。

As an important part of the internal environment of human,intestinal flora participates in and regulates the immune inflammatory response and metabolic process of the body.It is closely related to the occurrence and development of hypertension,and has become the focus of research on hypertension.The thesis summarizes the relationship between intestinal flora and hypertension,then clarifies their effects and possible mechanisms on hypertension in terms of inflammation and immune response,brain-intestine-bone marrow axis and metabolites,focusing on the new auxiliary antihypertensive pathways that dietary intervention affects intestinal flora to improve blood pressure from salt,probiotics and polyphenols.It is hoped that more in-depth research will come out on improving hypertension through dietary intervention and Chinese herbal medicine prevention and treatment with intestinal flora as the target.