血小板抗体、血小板配型及输注次数对血液病患者的临床价值

Clinical analysis on the effect of platelet antibody,platelet cross-matching and transfusion times on platelet transfusion in patients with hematological diseases

目的:观察分析血液病患者的血小板抗体、血小板配型及输注次数,为提高临床血小板输注治疗效果提供依据及指导。方法:回顾分析26例进行62次单采血小板输注的血液病患者的一般资料,通过血小板输注后24 h血小板计数增高指数(CCI)判定血小板输注疗效,分析血小板抗体检测(58次)、交叉配型(55次)和血小板输注次数对血小板输注效果的影响。结果:患者血小板输注后血小板计数(PLT)和血小板压积(PCT)水平较输注前升高(P<0.05);血小板交叉配型患者的输注前后PLT增值(P<0.05)及输注有效率阴性(72.73%)患者高于阳性(45.45%)患者(P<0.05);而做血小板交叉配型后,血小板抗体阳性与阴性患者输注前后PLT增值及输注有效率差异均无统计学意义(P>0.05);且患者输注次数对血小板输注效率有明显影响(P<0.05)。结论:血小板交叉配型及患者PLT输注次数对血小板输注疗效至关重要。

Objective:To observe and analyze the curative effect of platelet antibody,cross-match-compatible platelet components and transfusion times in patients with hematological disorder for evidence to improve platelet transfusion in clinic.Methods:The general information was obtained from and retrospectively analyzed in 26 patients undergone 62 apheresis platelet transfusions.Efficacy of platelet transfusion was determined by 24 h platelet corrected count increment(CCI),and the effects of platelet antibody testing(58 times),platelet cross-match(55 times)and transfusion times on the efficacy of platelet transfusion were analyzed.Results:The levels of platelet and plateletcrit were significantly increased after platelet transfusion(P<0.05).Platelet increment and transfusion efficiency of platelet cross-match-negative patients(72.73%)were significantly higher than those of patients with platelet cross-match-positive ones(45.45%)(both P<0.05),yet there was no significant difference in platelet increment and transfusion efficiency between patients with positive and negative platelet antibody before and after platelet infusion(P>0.05).Transfusion times had a significant impact on the efficiency of platelet transfusion(P<0.05).Conclusion:Platelet cross-matching and platelet transfusion frequencies can produce strong effect on platelet transfusion.