1例颈动脉蹼致急性缺血性脑卒中:基于计算流体力学分析

Acute ischemic stroke due to carotid webs:Computational fluid dynamics analysis in one case

目的:探讨颈动脉蹼(CW)血流动力学变化与缺血性脑卒中的关系。方法:结合计算流体力学总结并分析1例CW导致的急性缺血性脑卒中的临床病例资料并回顾相关文献。结果:通过计算流体力学结合文献分析,CW所处位置存在二次流漩涡,低壁面剪切力(WSS)、低剪切力震荡因子(OSI)、高相对滞留时间(RRT)可能是刺激血栓形成的因素,从而增加急性缺血性脑卒中的风险。结论:CW血流动力学变化是缺血性脑卒中发生的重要机制。

Objective:To investigate the relationship between the changes of carotid web hemodynamics and ischemic stroke.Methods:A case of acute ischemic stroke involved in carotid web artery was retrospectively analyzed by computational fluid dynamics(CFD),and related literatures were reviewed.Results:CFD analysis,together with review of the related literatures,demonstrated that presence of secondary flow vortexes at the location of carotid web,low wall shear stress(WSS),low shear force shock factor(OSI)and high relative residence time(RRT)were potential factors stimulating thrombosis,thus increasing the risk of acute ischemic stroke.Conclusion:The change of carotid web hemodynamics is an important mechanism of ischemic stroke.