奋乃静联合行为疗法对酒精中毒性精神病患者BPRS评分及血清神经元特异性烯醇化酶水平的影响

Effect of Perphenazine Combined with Behavior Therapy on BPRS Score and Serum Neuron-specific Enolase Level in Patients with Alcoholic Psychosis

目的:探究奋乃静联合行为疗法对酒精中毒性精神病患者简明精神病评定量表(brief psychiatric rating scale,BPRS)评分及血清神经元特异性烯醇化酶(neuron-specific enolase,NSE)水平的影响。方法:选取2018年1月-2020年12月宜春市第三人民医院接诊的50例酒精中毒性精神病患者,按照随机数字表法将患者分为对照组和观察组,每组25例。对照组接受奋乃静治疗,观察组在此基础上联合行为疗法治疗。比较两组疗效、治疗前后两组BPRS、简易智力状况评定量表(mini-mental state examination,MMSE)、生活质量评分及血清NSE、白介素-6(interleukin 6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平。结果:观察组总有效率为92.00%,高于对照组的68.00%,差异有统计学意义(P<0.05)。治疗后,两组BPRS评分均低于治疗前,MMSE评分均高于治疗前,且观察组BPRS评分低于对照组,MMSE评分高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组血清NSE、IL-6、TNF-α水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组社会功能、心理功能、躯体功能评分均高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组物质生活状态评分比较,差异无统计学意义(P>0.05)。结论:奋乃静联合行为疗法在酒精中毒性精神病患者治疗中效果较好,可以明显降低患者BPRS评分及血清NSE水平。

Objective:To explore the effect of Perphenazine combined with behavior therapy on the brief psychiatric rating scale (BPRS) score and serum neuron-specific enolase (NSE) level in patients with alcoholic psychosis.Method:A total of 50 patients with alcoholic psychosis admitted to the Third People’s Hospital of Yichun City from January 2018 to December 2020 were selected,they were divided into control group and observation group according to random number table method,with 25 patients in each group.The control group was treated with Perphenazine,and the observation group was treated with behavioral therapy on this basis.The efficacy,BPRS,mini-mental state examination (MMSE),quality of life scores,serum NSE,interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels before and after treatment were compared between two groups.Result:The total effective rate of the observation group was 92.00%,which was higher than 68.00% of control group,the difference was statistically significant (P<0.05).After treatment,BPRS scores of both groups were lower than those before treatment,MMSE scores of both groups were higher than those before treatment,BPRS score of the observation group was lower than that of the control group,MMSE score of the observation group was higher than that of the control group,the differences were statistically significant (P<0.05).After treatment,serum levels of NSE,IL-6 and TNF-α of both groups were lower than those before treatment,and those of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).After treatment,the scores of social function,psychological function and physical function of the observation group were higher than those of the control group,the differences were statistically significant (P<0.05).After treatment,there was no significant difference in the scores of material living status between two groups (P>0.05).Conclusion:Perphenazine combined with behavior therapy is effective in the treatment of patients with alcoholic psychosis,which can significantly reduce the BPRS score and serum NSE level of patients.