试管婴儿孕妇发生先兆流产的多因素分析

Multivariate Analysis of Threatened Abortion in Pregnant Women with IVF

目的:探讨试管婴儿孕妇发生先兆流产的相关影响因素,为预防试管婴儿孕妇的先兆流产提供临床依据。方法:选取2019年2月-2021年2月赣州市人民医院因先兆流产住院的试管婴儿孕妇174例为研究组,同期无先兆流产的试管婴儿孕妇184例为对照组,分析引发试管婴儿孕妇先兆流产的相关因素。结果:两组孕妇在不孕因素方面比较,差异有统计学意义(P<0.05),但在职业、文化程度、孕周、支原体感染、不孕类型、乙肝病毒表面抗原、乙肝病毒e抗原、乙肝病毒e抗体、乙肝病毒核心抗体、梅毒螺旋体抗体、不良妊娠史方面比较,差异均无统计学意义(P>0.05);两组在胚胎移植周期类型、胚胎移植数目以及心理状态方面比较,差异均有统计学意义(P<0.05);两组的受精、取精方式和子宫内膜类型比较,差异均无统计学意义(P>0.05);多因素分析结果显示,孕妇有焦虑情绪、抑郁情绪、移植胚胎的周期类型(解冻周期)、不孕因素(严重的输卵管疾病)、胚胎移植数目(3个)是导致先兆流产独立危险因素(P<0.05)。结论:孕妇伴有焦虑情绪、有抑郁情绪、移植胚胎的周期类型(解冻周期)、不孕因素(严重的输卵管疾病)、胚胎移植数目(3个)是导致先兆流产独立的危险因素,通过对此类因素进行分析,同时总结相应的对策,可以为胎儿提供健康的生长环境。

Objective:To explore the related factors of threatened abortion in pregnant women with IVF,so as to provide clinical basis for the prevention of threatened abortion in pregnant women with IVF.Method:A total of 174 cases of IVF pregnant women hospitalized for threatened abortion in Ganzhou People’s Hospital from February 2019 to February 2021 were selected as the study group,and 184 cases of IVF pregnant women without threatened abortion during the same period were selected as the control group.The related factors of threatened abortion in pregnant women with IVF were analyzed.Result:There were significant differences in infertility factors between the two groups (P<0.05),but there were no significant differences in occupation,education level,gestational age,mycoplasma infection,infertility type,hepatitis B virus surface antigen,hepatitis B virus e antigen,hepatitis B virus e antibody,hepatitis B virus core antibody,Treponema pallidum antibody and adverse pregnancy history (P>0.05).There were significant differences in embryo transfer cycle type,embryo transfer number and psychological state between the two groups (P<0.05),there were no significant differences in fertilization,sperm collection mode and endometrial type between the two groups (P>0.05);the results of multivariate analysis showed that anxiety,depression,cycle type of embryo transfer (thawing cycle),infertility factors (severe fallopian tube disease) and the number of embryo transfer (3) were independent risk factors for threatened abortion (P<0.05).Conclusion:The anxiety and depression of pregnant women,the cycle type of embryo transfer (thawing cycle),infertility factors (severe fallopian tube disease) and the number of embryo transfer (3) are independent risk factors leading to threatened abortion,by analyzing these factors and summarizing the corresponding countermeasures,we can provide a healthy growth environment for the fetus.