白血病患者输注去白红细胞的疗效及影响因素研究

Curative Effect of Infusion of Leukocyte-depleted Red Blood Cells on Patients with Leukemia and Its Influencing Factors

目的:研究急性白血病患者输注去白红细胞的治疗效果,并探讨影响去白红细胞疗效的相关因素。方法:回顾性分析2018年1月-2020年1月井冈山大学附属医院收治的80例急性白血病患者的临床资料,其中46例接受去白红细胞输注治疗为观察组,34例接受洗涤红细胞输注治疗为对照组。比较两组患者的疗效,分析影响去白红细胞疗效的相关因素。结果:对照组共输注红细胞172例次,其中有135例次有效,37例次无效,有效率为78.49%,观察组共输注红细胞224例次,其中有效167例次,无效57例次,有效率为74.55%。两组输注有效率比较,差异无统计学意义(P>0.05)。有效组和无效组患者的年龄、性别、疾病类型比较,差异均无统计学意义(P>0.05)。有效组和无效组患者的发热、感染及输注次数比较,差异均有统计学意义(P<0.05)。发热、感染及输注次数>5次均是影响去白红细胞输注疗效的独立危险因素(P<0.05)。结论:在急性白血病患者接受红细胞输注治疗中,去白红细胞的输注疗效与洗涤红细胞输注疗效相当。输注去白红细胞治疗前还需要密切关注患者的发热、感染等疾病情况,制定科学合理的输注方法,避免对患者进行盲目的反复输注,以确保输注疗效。

Objective:To study the curative effect of infusion of leukocyte-depleted red blood cells on patients with acute leukemia,and investigate its influencing factors.Method:The clinical data of 80 patients with acute leukemia admitted to the Affiliated Hospital of Jinggangshan University from January 2018 to January 2020 were retrospective analyzed.Among them,46 patients received leukocyte-depleted red blood cell infusion were treated as observation group,and 34 patients received washed erythrocyte infusion were treated as control group.The efficacy were compared between two groups,and the related factors affecting the curative effect of infusion of leukocyte-depleted red blood cells were analyzed.Result:There were 172 cases of red blood cell infusion in the control group,135 cases were effective and 37 cases were ineffective,the effective rate was 78.49%.There were 224 cases of red blood cell infusion in the observation group,167 cases were effective and 57 cases were ineffective,the effective rate was 74.55%.There was no significant difference in the infusion efficiency between two groups (P>0.05).There were no significant differences in age,gender and disease type between effective group and ineffective group (P>0.05).There were statistically significant differences in fever,infection and infusion times between effective group and ineffective group (P<0.05).Fever,infection and infusion times >5 were independent risk factors affecting the efficacy of erythrocyte infusion (P<0.05).Conclusion:Infusion of leukocyte-depleted red blood cells and infusion of washed red blood cells can achieve equivalent curative effect in the treatment of patients with acute leukemia.In addition,it is necessary to pay close attention to fever and infection to help formulate scientific and reasonable infusion method so as to avoid blindly repeated infusion and ensure the curative effect of infusion.