克拉霉素在慢性牙周炎中的疗效及对局部炎症反应的控制效果观察

Observation on the Effect of Clarithromycin in Patients with Chronic Periodontitis and Its Control Effect of Local Inflammatory Reaction

目的:观察与探究克拉霉素在慢性牙周炎中的疗效及对局部炎症反应的控制效果。方法:选取2017年10月-2020年10月上海交通大学医学院附属苏州九龙医院收治的84例慢性牙周炎患者,按照随机数字表法将其分为对照组和观察组,每组42例。对照组采用奥硝唑治疗,观察组采用克拉霉素治疗。比较两组的总有效率、牙周健康状况(牙周袋深度、牙龈指数、菌斑指数及龈沟出血指数)、龈沟液炎性指标[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)]及口腔健康程度(OHIP-14量表)。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组牙周袋深度、牙龈指数、菌斑指数和龈沟出血指数比较,差异均无统计学意义(P>0.05);治疗后1、2周,观察组牙周袋深度、牙龈指数、菌斑指数和龈沟出血指数均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组IL-1β、IL-6水平比较,差异均无统计学意义(P>0.05);治疗3、7 d,观察组IL-1β、IL-6水平均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组各维度OHIP-14评分比较,差异均无统计学意义(P>0.05);治疗后1、2周,观察组各维度OHIP-14量表评分均低于对照组,差异均有统计学意义(P<0.05)。结论:克拉霉素在慢性牙周炎中的疗效较好,且对局部炎症反应的控制效果较好,因此在慢性牙周炎中的应用价值相对较高。

Objective:To observe and investigate the effect of Clarithromycin in patients with chronic periodontitis and its control effect of local inflammatory reaction.Method:A total of 84 patients with chronic periodontitis admitted to Suzhou Jiulong Hospital Affiliated to Medical College of Shanghai Jiaotong University from October 2017 to October 2020 were selected,they were divided into control group and observation group according to random number table method,with 42 patients in each group.The control group was treated with Ornidazole and the observation group was treated with Clarithromycin.The total effective rate,periodontal health status (periodontal pocket depth,gingival index,plaque index and gingival sulcus bleeding index),inflammatory indexes of gingival crevicular fluid[interleukin-1β (IL-1β),interleukin-6 (IL-6)]and oral health degree (OHIP-14 scale) were compared between two groups.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in periodontal pocket depth,gingival index,plaque index and gingival sulcus bleeding index between two groups (P>0.05);at 1 and 2 weeks after treatment,periodontal pocket depth,gingival index,plaque index and gingival sulcus bleeding index of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in the levels of IL-1β and IL-6 between two groups (P>0.05);3 and 7 d of treatment,the levels of IL-1β and IL-6 of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in all dimension of OHIP-14 scores between two groups (P>0.05);at 1 and 2 weeks after treatment,the all dimension of OHIP-14 scale scores of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).Conclusion:The effect of Clarithromycin in patients with chronic periodontitis is better,and its control effect for local inflammatory reaction is better too,so its application value in the patients with chronic periodontitis is relatively higher.