动脉粥样硬化的血清主要危险因子在急性脑梗死患者中的表达及与NIHSS评分的关系

The Expression of Major Serum Risk Factors of Atherosclerosis in Patients with Acute Cerebral Infarction and Its Relationship with NIHSS Score

目的:探究动脉粥样硬化的血清主要危险因子在急性脑梗死患者中的表达及与国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分的关系。方法:选取2019年1月-2020年12月佳木斯市中心医院收治的急性脑梗死患者40例纳入疾病组,同时期健康人群40例作为正常组。两组均进行临床资料的收集、血清指标的检测,评定疾病组患者的NIHSS评分并进行严重程度的划分。对比两组临床资料、动脉粥样硬化的血清主要危险因子(Hcy、Cys C、FIB)水平,分析血清主要危险因子水平与NIHSS评分的关系。结果:两组的性别、年龄、吸烟、饮酒、患有冠心病情况对比,差异均无统计学意义(P>0.05)。疾病组患有高血压、糖尿病、血脂异常例数均多于正常组(P<0.05)。与正常组比较,疾病组的Hcy、Cys C、FIB均较高,差异均有统计学意义(P<0.05)。不同NIHSS评分间的各项血清主要危险因子对比,差异均有统计学意义(P<0.05);中重度者的各项血清主要危险因子水平均高于中度者,中度者上述指标均高于轻微者,差异均有统计学意义(P<0.05)。Spearman相关性分析结果显示,Hcy、Cys C、FIB水平均与NIHSS评分呈现正相关关系(r;=0.512、0.547、0.608,P<0.05)。结论:急性脑梗死患者中的动脉粥样硬化的血清主要危险因子水平(Hcy、Cys C、FIB)均呈现异常状态,且与NIHSS评分密切相关,在一定程度上反映了患者的疾病严重程度。在日常诊疗中需要加强对上述血清指标的监测,以方便临床医生及时掌握患者病情并有效进行预后评估。

Objective:To explore the expression of the main risk factors of atherosclerosis in patients with acute cerebral infarction and its relationship with the National Institutes of Health Stroke Scale (NIHSS) score.Method:A total of 40 patients with acute cerebral infarction admitted to Jiamusi Central Hospital from January 2019 to December 2020 were included in the disease group,and 40 healthy people in the same period were selected as the normal group.Clinical data were collected,serum indexes were tested,NIHSS scores of patients in the disease group were evaluated and severity was divided.Clinical data and the levels of Hcy,Cys C and FIB were compared between the two groups,and the relationship between the levels of main risk factors and NIHSS score was analyzed.Result:There were no significant differences in gender,age,smoking,drinking and coronary heart disease between the two groups (P>0.05).The number of hypertension,diabetes mellitus and dyslipidemia in disease group were higher than those in normal group (P<0.05).Compared with normal group,Hcy,Cys C and FIB were higher in disease group,the differences were statistically significant (P<0.05).There were statistically significant differences in the main serum risk factors among different NIHSS scores (P<0.05),the levels of major risk factors in serum of moderate and severe patients were higher than those of moderate patients,and those of moderate patients were higher than those of mild patients,with statistical significance (P<0.05).Spearman correlation analysis showed that Hcy,Cys C and FIB levels were positively correlated with NIHSS score (r;=0.512,0.547,0.608,P<0.05).Conclusion:The main serum risk factors of atherosclerosis (Hcy,Cys C and FIB) in patients with acute cerebral infarction are all abnormal,and are closely related to the NIHSS score,to a certain extent,they reflect the severity of the patient’s disease.In daily diagnosis and treatment,it is necessary to strengthen the above the monitoring of serum indicators is convenient for clinicians to grasp the patient’s condition in time and effectively evaluate the prognosis.