上皮性卵巢癌发病危险因素及初次治疗后预后的影响因素分析

Risk Factors of Epithelial Ovarian Cancer and Influencing Factors of Prognosis after Initial Treatment

目的:分析上皮性卵巢癌发病危险因素及初次治疗后影响预后的相关因素,为上皮性卵巢癌的诊治和预防提供临床依据。方法:回顾性分析2012年8月-2017年3月四会市人民医院收治的80例上皮性卵巢癌患者的临床资料,并选取同期在本院住院治疗的80例非恶性肿瘤患者为对照组。探究上皮性卵巢癌发病的相关危险因素以及初次治疗后影响患者预后质量的相关因素。结果:观察组与对照组在初潮年龄、月经期、痛经、妊娠次数、自然流产史、人工流产史方面比较,差异均有统计学意义(P<0.05),而两组在月经周期、累计月经年数及子宫肌瘤方面比较,差异均无统计学意义(P>0.05)。多因素分析显示,自然流产史、人工流产史及月经期为影响上皮性卵巢癌发病的独立危险因素(P<0.05)。初次治疗年龄<51岁、绝经、术后病灶残留<1 cm、肿瘤为中高分化、术后化疗次数≥6次以及无术后并发症患者的3年生存率分别高于初次治疗年龄≥51岁、未绝经、术后病灶残留≥1 cm、肿瘤为低分化、术后化疗次数<6次以及有术后并发症的患者,差异均有统计学意义(P<0.05)。术后病灶残留≥1 cm、术后并发症的发生及术后化疗次数<6次是影响上皮性卵巢癌预后的独立危险因素(P<0.05)。结论:通过分析上皮性卵巢癌发病危险因素及初次治疗后预后影响因素,可为卵巢癌的预防及初次治疗后提升预后质量、延长生存期提供依据。

Objective:To analyze the risk factors of epithelial ovarian cancer and the related factors affecting the prognosis quality after initial treatment,so as to provide clinical basis for the diagnosis,treatment and prevention of epithelial ovarian cancer.Method:The data of 80 patients with epithelial ovarian cancer admitted to Sihui People’s Hospital from August 2012 to March 2017 were retrospectively analyzed,80 patients with non-malignant tumor who were hospitalized in our hospital during the same period were selected as the control group.The risk factors related to the occurrence of epithelial ovarian cancer and the related factors affecting the prognosis quality of patients after initial treatment were explored.Result:There were significant differences in menarche age,menstrual period,dysmenorrhea,number of pregnancies,history of spontaneous abortion and history of induced abortion between the observation group and the control group (P<0.05),but there were no significant differences in menstrual cycle,cumulative menstrual years and uterine leiomyoma between the two groups (P>0.05).Multivariate analysis showed that history of spontaneous abortion,history of induced abortion and menstrual period were independent risk factors affecting the incidence of epithelial ovarian cancer (P<0.05).The 3-year survival rates in patients with initial treatment age <51 years old,menopause,postoperative focus residue <1 cm,the tumor is moderately well differentiated,postoperative chemotherapy times ≥6 times and no postoperative complications were significantly higher than those with initial treatment age ≥51 years old,premenopausal,postoperative focus residue ≥1 cm,the tumor is poorly differentiated postoperative chemotherapy times <6 times and postoperative complications,the differences were statistically significant (P<0.05).The residual focus ≥1 cm,the occurrence of postoperative complications and the number of postoperative chemotherapy <6 were independent risk factors affecting the prognosis of epithelial ovarian cancer (P<0.05).Conclusion:By analyzing the risk factors of epithelial ovarian cancer and the influencing factors of prognosis quality after initial treatment,can provide evidence for the prevention of ovarian cancer and the improvement of prognosis quality and prolongation of survival after initial treatment.