线粒体及其蛋白质质量控制失调与动脉粥样硬化的关系

Mitochondria and its protein quality control disorder and atherosclerosis

线粒体是哺乳动物细胞内重要的细胞器,作为细胞能量代谢和细胞死亡的调控中心,其功能异常会导致多种疾病的发生与发展。线粒体功能依赖于线粒体蛋白质组的完整性和稳态,因此线粒体蛋白质质量控制系统对于维持线粒体稳态和机体健康十分重要。当线粒体及其蛋白质质量控制系统出现异常时,会直接损伤线粒体并出现异常线粒体蛋白堆积,发生细胞内环境紊乱,甚至细胞功能障碍,进而影响动脉粥样硬化性疾病的发生与发展。文章回顾了线粒体及其蛋白质质量控制系统在动脉粥样硬化性疾病发生发展中的作用,并对该领域未来的发展前景和挑战进行展望,以期为寻找与动脉粥样硬化性疾病密切相关的特异性线粒体蛋白提供线索。

Mitochondria are important organelles in mammalian cells.As the regulatory center of cell energy metabolism and cell death,mitochondrial dysfunction will lead to the occurrence and development of a variety of diseases.Mitochondrial function depends on the integrity and homeostasis of mitochondrial proteome.Therefore,mitochondrial protein quality control system is very important to maintain mitochondrial homeostasis and body health.When mitochondria and their protein quality control system are abnormal,it will directly damage mitochondria and lead to abnormal mitochondrial protein accumulation,resulting in intracellular environmental disorder and even cell dysfunction,which may affect the occurrence and development of atherosclerotic diseases.This paper reviews the role of mitochondria and its protein quality control system in the occurrence and development of atherosclerotic diseases,and looks forward to the future development prospects and challenges in this field,in order to providing scientific evidence for finding specific mitochondrial protein closely related to atherosclerotic diseases.