腹主动脉瘤动物模型的研究现状和进展

Research status and progress of animal models of abdominal aortic aneurysm

腹主动脉瘤是常见的动脉扩张性疾病,其起病隐匿且发病机制复杂,由于缺乏早期诊断和有效的干预措施,动脉瘤一旦破裂致死率高。因此,进一步探索其发病机制及寻找有效的治疗措施迫在眉睫。由于在人体试验存在诸多局限,复制动物模型进行腹主动脉瘤的研究非常必要。本文将根据不同的研究目的分类介绍一些经典的和具有创新性的动物模型,以及它们各自的特点、应用价值,为研究者选择合适的动物模型提供帮助。

Abdominal aortic aneurysm is a common arterial dilatation disease,with insidious onset and complicated pathogenesis.Due to the lack of early diagnosis and effective intervention measures,the mortality rate of aneurysm is high once ruptured.Therefore,it is urgent to further explore its pathogenesis and find effective treatment measures.Due to many limitations in human trials,it is necessary to replicate animal models for the study of abdominal aortic aneurysms.This article will classify and introduce some classic and innovative animal models according to different research purposes,as well as their respective characteristics and application values,and provide help for researchers to choose appropriate animal model.