对比胺碘酮与利多卡因在急性心肌梗死院前急救中的应用效果

Comparison the effect of amiodarone and lidocaine in pre hospital emergency treatment of acute myocardial infarction

目的探究在急性心肌梗死患者院前急救治疗中应用胺碘酮和利多卡因的效果差异。方法选取2020年1—6月本中心急救科救治的92例急性心肌梗死患者作为研究对象,根据院前急救中所用药物的不同分为两组,各46例。对照组给予利多卡因,干预组给予胺碘酮,比较两组治疗前后的血气分析指标、心率、QTc间期、抢救成功情况、心肌梗死复发情况及除颤次数和住院时间。结果治疗后,两组动脉血氧分压(PaO_(2))水平均高于治疗前,动脉血二氧化碳分压(PaCO_(2))水平和心率均低于治疗前,QTc期间均长于治疗前(P<0.05);且干预组PaO_(2)水平高于对照组,PaCO_(2)水平和心率均低于对照组,QTc期间长于对照组(P<0.05)。干预组抢救成功率高于对照组(P<0.05);心肌梗死复发率低于对照组(P<0.05)。干预组除颤次数少于对照组,住院时间短于对照组(P<0.05)。结论在急性心肌梗死患者院前急救治疗中应用胺碘酮的效果明显优于利多卡因,且患者复发率显著降低,除颤次数减少,住院时间短,具有更高的临床应用价值。

Objective To investigate the effect difference of amiodarone and lidocaine in in pre hospital emergency treatment of patients with acute myocardial infarction.Methods A total of 92 patients with acute myocardial infarction treated as in department from January to June 2020were selected as the research subject,and they were divided into two groups according to the different drugs used in pre hospital first aid,with 46 cases in each group.The control group was given lidocaine and the intervention group was given amiodarone,the blood gas indexes,heart rate,QTc interval,rescue success,recurrence of myocardial infarction,defibrillation times and hospitalization time were compared between the two groups before and after treatment.Results After treatment,the level of arterial partial pressure of oxygen(PaO_(2))was significantly higher than that before treatment,the level of arterial partial pressure of carbon dioxide(PaCO_(2))and heart rate were significantly lower than those before treatment,and the QTc period was significantly longer than that before treatment(P<0.05);the level of PaO_(2)in the intervention group was higher than that of the control group,the level of PaCO_(2)and heart rate were lower than those in the control group,and the QTc period was longer than that of the control group(P<0.05).The success rate of rescue in the intervention group was significantly higher than that in the control group(P<0.05);the recurrence rate of myocardial infarction was significantly lower than that in the control group(P<0.05).The frequency of defibrillation in the intervention group was significantly lower than that in the control group,and the hospitalization time was significantly shorter than that of control group(P<0.05).Conclusion In the pre hospital emergency treatment of patients with acute myocardial infarction,the effect of amiodarone is significantly better than lidocaine,and the recurrence rate of patients is significantly reduced,the number of defibrillation is less,the hospitalization time is short;It has higher clinical application value.