观察重复经颅磁刺激对缺血性脑卒中失眠患者的临床疗效

To Observe the Clinical Effect of Repeated Transcranial Magnetic Stimulation on Insomnia Patients with Ischemic Stroke

目的:观察重复经颅磁刺激技术(rTMS)治疗缺血性脑卒中失眠患者的临床疗效。方法:选取2019年10月至2020年10月泉州市第一医院神经内科收治的缺血性脑卒中继发失眠患者90例作为研究对象,按照随机数字表法分为观察组和对照组,每组45例。对照组患者给予右佐匹克隆治疗,观察组患者给予rTMS治疗。发放睡眠情况调查问卷,比较2组患者的入睡时间、觉醒次数、觉醒时间,采用匹兹堡睡眠质量指数(PSQI)比较2组患者干预前后的睡眠质量变化,采用抑郁自评量表(SDS)、焦虑自评量表(SAS)比较2组患者焦虑以及抑郁状态改善情况。结果:治疗后,观察组入睡时间、觉醒时间短于对照组,觉醒次数少于对照组,2组比较差异均有统计学意义(均P<0.05);治疗后,观察组PSQI评分、SAS评分、SDS评分均低于对照组,2组比较差异均有统计学意义(均P<0.05)。结论:重复经颅磁刺激技术治疗缺血性脑卒中继发失眠的患者疗效显著,能有效延长患者睡眠时间,减少觉醒次数,有效改善患者的睡眠质量,改善患者焦虑及抑郁情绪。

Objective:To investigate the clinical efficacy of repetitive Transcranial Magnetic Stimulation(rTMS)in the treatment of ischemic stroke patients with insomnia.Methods:A total of 90 patients with insomnia secondary to ischemic stroke in the Department of Neurology of Quanzhou First Hospital from October 2019 to October 2020 were selected as the research objects,and were divided into observation group and control group according to the random number table method,with 45 patients in each group.Control group was treated with dexzopiclone,and observation group was treated with rTMS.A Sleep questionnaire was issued to compare the sleep time,wake times between 2 groups.Pittsburgh Sleep Quality Index(PSQI)was used to compare the sleep quality changes of the 2 groups before and after intervention.Self-rating Depression Scale(SDS)and Self-rating Anxiety Scale(SAS)were used to compare the improvement of anxiety and depression between 2 groups.Results:After treatment,the time of falling asleep and waking up in observation group was shorter than that in the control group,and the number of waking up was less than that in the control group,the differences between the two groups were statistically significant(Ps<0.05).After treatment,PSQI score,SAS score and SDS score in the observation group were lower than those in the control group,and the differences between the two groups were statistically significant(Ps<0.05).Conclusion:RTMS has significant efficacy in the treatment of insomnia secondary to ischemic stroke,which can effectively prolong the sleep time of patients,reduce the number of awakenings,effectively improve the sleep quality of patients,and improve the anxiety and depression of patients.