帕罗地汀联合奥氮平治疗抑郁症并发睡眠障碍对患者睡眠质量的影响

Clinical Efficacy and Adverse Drug Reactions of Parodipine Combined with Olanzapine in the Treatment of Depression Complicated with Sleep Disorders

目的:观察帕罗地汀联合奥氮平治疗抑郁症并发睡眠障碍对患者睡眠质量的影响,为临床应用提供科学依据。方法:选取2018年1月至2019年1月济南市公共卫生临床中心收治的抑郁症并发睡眠障碍患者60例作为研究对象,随机分为对照组和观察组,每组30例。对照组采用帕罗地汀治疗,观察组在对照组治疗的基础上加用奥氮平治疗,观察比较2组患者匹兹堡睡眠质量指数(PSQI)评分。结果:治疗后,观察组的睡眠质量、入睡时间、睡眠时间、睡眠效率、日间功能障碍、催眠药物等评分以及PSQI总分与对照组比较,差异均有统计学意义(均P<0.05)。结论:采用罗地汀联合奥氮平治疗抑郁症并发睡眠障碍患者疗效显著,能够有效治疗抑郁症患者的睡眠障碍,无不良反应,值得推广应用。

Objective:To observe the clinical effect of paroxetine combined with olanzapine on the basis of clinical analysis of patients with depression complicated with sleep disorders.Methods:A total of 60 patients from January 2018 to January 2019 were selected and randomly divided into control group and observation group according to different treatment methods,with 30 cases in each group.The control group was treated with paroxetine and the observation group was treated with olanzapine on the basis of the treatment of the control group.The Pittsburgh Sleep Quality Index(PSQI)scores of the two groups were observed and compared.Results:The results showed that after treatment,patients had significant differences in sleep quality,sleep time,sleep time,efficiency,disorder and hypnotic drugs,the relevant score of the observation group was better and the total score was also significantly different(Ps<0.05).Conclusion:The combination of the two can effectively treat sleep disorders in patients with depression,and there is no adverse drug reaction,which is worthy of promotion.