美金刚与多奈哌齐对老年阿尔茨海默病患者日常生活能力、BNP水平的影响比较

Comparison of the Effects of Memantine and Donepezil on the Ability of Daily Living and BNP Level in Elderly Patients with Alzheimer’s Disease

目的:比较美金刚与多奈哌齐在老年阿尔兹海默病(AD)患者中的应用效果。方法:回顾性分析2020年1月-2021年4月于赣州市第三人民医院就诊的68例老年AD患者的病历资料,依照治疗方法不同将其分为对照组与观察组,各34例。对照组给予多奈哌齐治疗,观察组给予美金刚治疗,连续治疗3个月。对比两组临床疗效、日常生活能力、脑钠肽(BNP)、认知功能和不良反应发生情况。结果:观察组治疗总有效率为94.12%,高于对照组的76.47%(P<0.05)。治疗前,两组日常生活能力量表(ADL)评分、BNP、简易智能量表(MMSE)评分相比,差异均无统计学意义(P>0.05);治疗后,观察组ADL、MMSE评分均高于对照组,且BNP水平低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:相较于多奈哌齐,美金刚在老年AD患者治疗中效果更佳,能够显著提高其日常生活能力与认知功能,减少心功能损伤,安全可靠。

Objective:To compare the efficacy of memantine and Donepezil in elderly patients with Alzheimer’s disease(AD).Method:The medical records of 68 elderly AD patients admitted to Ganzhou Third People’s Hospital from January 2020 to April 2021 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,with 34 cases in each group.Control group was given Donepezil treatment,observation group was given Memantine treatment,continuous treatment for 3 months.Clinical efficacy,daily living ability,brain natriuretic peptide(BNP),cognitive function and incidence of adverse reactions were compared between the two groups.Result:The total effective rate of observation group was 94.12%,higher than 76.47%of control group(P<0.05).Before treatment,there were no significant differences in activity of daily living scale(ADL)score,BNP and mini-mental state examination(MMSE)score between the two groups(P>0.05);after treatment,ADL and MMSE scores in observation group were higher than those in control group,and BNP level was lower than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compared with Donepezil,Memantine is more effective in the treatment of elderly patients with AD.It can significantly improve the ability of daily living and cognitive function,reduce heart damage,and is safe and reliable.