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活细胞药物体内可视化研究进展 被引量:2

Advances in research on visualization of living cell drugs in vivo
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摘要 活细胞药物的研发以及治疗的成功实施均需要充分阐明移植后的细胞命运,这对活细胞药物的有效性和安全性至关重要。为了解决这一问题,细胞成像技术进入人们视线,利用可视化技术对活细胞药物进行无创示踪,可以了解活细胞药物在体内的分布、归巢、活性等,有助于确定最佳的移植细胞数量、优化给药方案、提高移植效率、增强作用的靶向性、降低潜在的靶外积累风险。本文从放射性核素成像技术、磁共振成像技术、磁颗粒成像技术、计算机断层扫描成像技术、荧光成像技术以及多模态成像技术综述了活细胞药物体内无创可视化示踪的研究进展,旨在指导应用合适的造影剂和示踪技术,获得活细胞药物在体内的生物学行为,为活细胞药物研发及其移植治疗提供更加合理的科学依据。 The development of living cell drugs and their successful application in clinical treatments require full clarification of the fate of cells after transplantation,which is critical to the safety and efficacy of living cell drugs.In order to solve this problem,cell imaging technology has come into our sight,and the use of visualization technology for non-invasive tracing of living cell drugs could reveal the distribution,homing and activity of living cell drugs in the body,which helps to determine the best number of transplanted cells,optimize the administration scheme,improve the transplantation efficiency,enhance the targeting of transplanted cells,and reduce the potential off-target accumulation risk.This paper summarizes the research advances of non-invasive visual tracing in vivo for living cell drugs from the perspectives of radionuclide imaging,magnetic resonance imaging,magnetic particle imaging,computed tomography imaging,fluorescence imaging and multimodal imaging.The aim is to obtain the biological behavior of living cell drugs in vivo with the application of appropriate contrast agent and tracing technology,and provide a more reasonable scientific basis for the research and development of living cell drugs and their transplantation therapy.
作者 魏奶杰 王广基 张经纬 WEI Naijie;WANG Guangji;ZHANG Jingwei(Key Labratory Jiangsu Provincial of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,China)
出处 《中国药科大学学报》 CAS CSCD 北大核心 2022年第2期156-163,共8页 Journal of China Pharmaceutical University
基金 国家自然科学基金资助项目(No.82173887,No.82073928)。
关键词 活细胞药物 体内成像 CAR-T细胞 间充质干细胞 进展 living cell drug in vivo imaging CAR-T cell mesenchymal stem cells advances
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