胃癌患者腹腔镜术后复发情况与肝激酶B1的相关性分析

Correlation analysis between recurrence of gastric cancer patients af­ter laparoscopic surgery and liver kinase B1

目的:探讨胃癌患者腹腔镜术后复发情况与肝激酶B1(LKB1)的相关性分析。方法:选取在本院医治的60例胃癌患者,按照随机数字表法分为两组,观察组与对照组(30例/组)。给予对照组常规开腹手术,观察组腹腔镜胃癌根治术,对比两组术后复发情况;术后复发组有36例,未复发组有24例,对比复发组和未复发组患者术前临床病理情况;并分析腹腔镜术后患者的病理特征、LKB1阳性率与复发率的相关性。结果:对照组和观察组患者在术后1、2、3、5年的复发率无明显差别(P>0.05);复发组与未复发组在手术前的性别、肿瘤位置比较无显著性(P>0.05),但两组患者年龄、肿瘤直径、病理淋巴结和转移(tumor,nodal-involvement,metastasis,TNM)分期和LKB1阳性率对比差异显著(P<0.05);患者术后复发与性别、肿瘤位置无明显联系(P>0.05),但术后复发与年龄、肿瘤直径和TNM分期情况呈正相关(P<0.05),LKB1阳性率与腹腔镜术后复发情况呈负相关(P<0.05)。结论:胃癌患者无论是通过传统开腹手术还是腹腔镜胃癌根治术对于术后复发情况并无明显差别,术后复发情况多由患者的年龄、肿瘤直径、TNM分期和LKB1所影响,且LKB1的表达与腹腔镜术后复发情况呈负相关,因此也可以应用LKB1来预测胃癌患者术后的复发情况。

Objective:To investigate the correlation analysis between the recurrence of gastric cancer patients after laparoscopic surgery and liver kinase B1(LKB1).Methods:Sixty patients with gastric cancer treated in our hospital were selected and divided into 2 groups according to the random number table method,observation group and control group(30 cases/group).The control group was given conventional open surgery,and the observation group was given laparoscopic radical gastric cancer surgery to compare the postoperative recurrence of the two groups.There were 36 cases in the postoperative recurrence group and 24 cases in the non-recurring group,compared with the recurrence group and the non-recurring group before surgery Clinicopathological conditions,and analyze the pathological characteristics of patients after laparoscopic surgery,the correlation between the positive rate of LKB1 and the recurrence rate.Results:There was no significant difference in the recurrence rate of patients with conventional laparotomy and laparoscopic radical gastrectomy at 1,2,3,and 5 years after surgery(P>0.05),gender and tumor before surgery in the recurrence group and the non-recurrence group,The location comparison was not significant(P>0.05),but the two groups of patients had significant differences in age,tumor diameter,pathological lymph nodes and metastasis(tumor,nodal-involvement,metastasis,TNM)staging and LKB1 positive rate(P<0.05).Postoperative recurrence was not significantly related to gender and tumor location(P>0.05),but postoperative recurrence was positively correlated with age,tumor diameter,and TNM stage(P<0.05),and the positive rate of LKB1 was negative correlation with recurrence after laparoscopic surgery(P<0.05).Conclusion:There is no significant difference in the recurrence of gastric cancer patients whether through traditional open surgery or laparoscopic radical gastric cancer surgery.Postoperative recurrence is mostly affected by the patient’s age,tumor diameter,TNM stage and liver kinase B1,and The expression of this gene is negatively correlated with recurrence after laparoscopic surgery,so liver kinase B1 can also be used to predict the recurrence of gastric cancer patients after surgery.