胃癌根治D2淋巴结清扫术中应用右美托咪定辅助全麻的临床意义研究

Clinical significance of dexmedetomidine assisted general anesthesia in radical gastrectomy with D2 lymph node dissection for gastric cancer

目的:分析胃癌根治D2淋巴结清扫术中应用右美托咪定辅助全麻的临床意义。方法:本试验择取2018年5月22日至2020年5月22日甘肃省庆阳市人民医院所收治的48例胃癌患者为研究样本。将其分为两组,每组各24例。观察组应用右美托咪定完成麻醉诱导,15 min后药物剂量变更为0.4μg/kg,手术前半小时停用药物。对照组应用等量生理盐水。对所有患者实施腹腔镜辅助胃癌D2淋巴结清扫术,分析结果。结果:相较于对照组,观察组术后不良反应发生率更低(P<0.05)。相较于对照组,观察组手术之后1~4 h的VAS分数明显更低;观察组术后1~4 h Ramsay镇静分数更高(P<0.05),相较于对照组,观察组麻醉药物用量显著更低(P<0.05)。结论:针对于接受腹腔镜胃癌根治D2淋巴结清扫术的患者来讲,在为其施麻醉过程中,应用右美托咪定能够在根本上降低机体应激反应,强化镇痛以及镇静效果,降低麻醉药物应用剂量,因而值得推广。

Objective:To analyze the clinical significance of dexmedetomidine assisted general anesthesia in radical gastrectomy with D2 lymph node dissection for gastric cancer.Methods:In this study,48 patients with gastric cancer admitted to Qingyang People's Hospital of Gansu Province from May 22,2018 to May 22,2020 were selected as study samples.The control group received the same amount of saline.Laparoscopic-assisted D2 lymph node dissection for gastric cancer was performed in all patients and the results were analyzed.Results:Compared with the control group,the incidence of postoperative adverse reactions was lower in the observation group(P<0.05).Compared with the control group,the VAS score at 1-4 h after surgery was significantly lower in the observation group.Postoperative 1-4 hramsay sedation score was higher in the observation group(P<0.05).Compared with the control group,the dosage of anesthetic drugs in the observation group was significantly lower(P<0.05).Conclusion:For patients undergoing laparoscopic radical gastrectomy with D2 lymph node dissection,the application of dexmedetomidine can fundamentally reduce stress response,enhance analgesic and sedative effects,and reduce the applied dose of anesthetic drugs during anesthesia,so it is worthy of promotion.