生物钟基因Cry1与动脉粥样硬化相关性研究进展

Research progress on the correlation between Cry1 and atherosclerosis

昼夜节律(circadian rhythm)是机体长期适应周围外界环境变化所产生的一种内在机制,控制这一节律的系统称为生物钟。生物钟基因调节多种生理反应,其表达紊乱可导致生物体一系列相关疾病的发生和发展,严重影响机体健康与生存。近年来大量的研究发现,生物钟基因Cry1的表达异常影响着动脉粥样硬化的发展。该文就生物钟基因Cry1在动脉粥样硬化中的影响及其可能的机制进行综述。

Circadian rhythm is an internal adaptation mechanism produced by the body's long-term adaptation to changes in the external environment.The system that controls this rhythm is called circadian clock.The clock genes regulate multiple physiological responses,while the disorder of their expression causes the occurrence and development of a series of diseases,seriously affecting the body health and survival.In recent years,a large number of studies have revealed that the abnormal expression of Cry1 affects the development of atherosclerosis.Here,we summarize the role of Cry1 in atherosclerosis and its mechanisms.