血清铁蛋白与肝损伤的相关性研究

The relationship between serum ferritin and liver injury

目的探讨肝病患者血清铁蛋白水平与肝损伤指标天门冬氨酸氨基转移酶(Aspartate aminotransferase,AST)、丙氨酸氨基转移酶(Alanine aminotransferase,ALT)之间的关系。方法回顾性分析138例健康体检者、慢性肝炎、肝硬化和肝癌患者的临床资料,收集整理患者的AST、ALT及血清铁蛋白水平,通过单因素方差分析、Spearman秩相关等方法检验肝病患者血清铁蛋白水平与肝损伤指标AST、ALT之间的关系。结果与健康体检者的血清水平比较,慢性肝炎、肝硬化及肝癌患者的血清AST水平均显著性升高(P=0.024,0.001,0.000);肝硬化、肝癌患者血清ALT水平均明显上升(P=0.018,0.000);肝硬化、肝癌患者的血清铁蛋白水平均显著上升(P=0.022,0.000)。肝癌患者血清铁蛋白水平较慢性肝炎、肝硬化患者均明显升高(P=0.000,0.011)。Spearman秩相关测试结果显示,慢性肝炎、肝硬化、肝癌患者的血清的铁蛋白水平与AST水平之间存在显著的正性相关系(r=0.423,P=0.014;r=0.353,P=0.019;r=0.441,P=0.012);慢性肝炎、肝硬化、肝癌患者的血清的铁蛋白水平与ALT水平之间存在显著的正性相关系(r=0.417,P=0.016;r=0.479,P=0.001;r=0.648,P=0.000)。结论血清铁蛋白水平可作为慢性肝炎、肝硬化、肝癌患者肝脏损伤的重要参考指标,对于判断病情、了解预后有着重要意义。

Objective To investigate the relationship between serum ferritin level and liver injury index AST,ALT in patients with liver disease.Methods The clinical data of 138 healthy people,patients with chronic hepatitis,liver cirrhosis and liver cancer were retrospectively analyzed.The levels of AST,ALT and serum ferritin were collected.The relationship between serum ferritin level and liver injury index AST,ALT was tested by One-Way ANOVA and Spearman rank correlation.Results Compared with the serum levels of healthy people,the serum AST levels of patients with chronic hepatitis,liver cirrhosis and liver cancer exhibited significantly higher(P=0.024,0.001,0.000);the serum ALT level of patients with liver cirrhosis and liver cancer increased significantly(P=0.018,0.000);the serum ferritin level of patients with liver cirrhosis and liver cancer increased significantly(P=0.000,0.011).Spearman rank correlation test showed that there was a significant positive correlation between serum ferritin level and AST level in patients with chronic hepatitis,liver cirrhosis and liver cancer(r=0.423,P=0.014;r=0.353,P=0.019;r=0.441,P=0.012);at the same time,there was a significant positive correlation between serum ferritin level and ALT level in patients with chronic hepatitis,liver cirrhosis and liver cancer(r=0.417,P=0.016;r=0.479,P=0.001;r=0.648,P=0.000).Conclusion Serum ferritin level can be used as an important reference index of liver injury in patients with chronic hepatitis,cirrhosis and liver cancer,which is of great significance for judging the patient’s condition and understanding the prognosis.