特异性促炎症消退介质在糖尿病血管病变中的研究进展

Specialized Pro-Resolving Lipid Mediator in Diabetic Vasculopathy

特异性促炎症消退介质(SPM)介导炎症消退过程,其生物作用包括减弱内皮细胞活化、阻断中性粒细胞外渗、调节免疫细胞功能、促进中性粒细胞凋亡及巨噬细胞吞噬作用等。慢性炎症是糖尿病(DM)及相关血管并发症的致病因素,SPM可促进炎症的消退并减轻DM的微血管和大血管并发症,有望成为治疗DM及其血管病变新的治疗靶点,现就近年来SPM在DM及其血管病变中的相关研究进展做一综述。

The specialized pro-resolving lipid mediator(SPM)mediates the process of inflammation resolution,and it regulates multiple biological effects include decreasing endothelial cell activation,blocking neutrophil extravasation,regulating immune cell function,promoting neutrophil apoptosis and macrophage phagocytosis.Chronic inflammation is a pathogenic factor for diabetes mellitus(DM)and related vascular complications.SPM can promote the extinction of inflammation and reduce the complications of microvascular and macrovascular in DM,which is expected to become a new therapeutic target for DM and vascular diseases.This article reviews the recent progress of SPM in DM and its vasculopathy.