射血分数保留性心力衰竭左心室心肌力学变化及评估的研究进展

Changes and Evaluation of Left Ventricular Myocardial Mechanical in Heart Failure with Preserved Ejection Fraction

射血分数保留性心力衰竭(HFpEF)是一组以心肌顺应性减低、心室主动舒张和被动充盈功能障碍、左心室充盈压增高为特征的临床综合征,约占心力衰竭总数的50%。近年来HFpEF的发病率和病死率逐年上升,其心肌力学的改变和评估是心血管研究热点之一,早期诊断对该病的治疗和预后极为关键。现就HFpEF患者心肌力学的改变以及对其心脏功能评估的研究进展做一综述。

Heart failure with preserved ejection fraction(HFpEF)is a group of clinical syndromes characterized by decreased myocardial compliance,dysfunction of ventricular active diastolic and passive filling,and increased left ventricular filling pressure,accounting for about 50%of the total heart failure.In recent years,the incidence rate and mortality of HFpEF have increased year by year.The changes and evaluation of myocardial mechanics is one of the hot topics in cardiovascular research.Early diagnosis is very critical for the treatment and prognosis of this disease.This article reviews the changes of left ventricular myocardial mechanics and the evaluation of cardiac function in HFpEF patients.