Annexin A2在病毒复制周期中的作用的研究进展

Research Progress on the Role of Annexin A2 in Virus Infection

膜联蛋白A2(AnxA2)是钙离子依赖的磷脂结合蛋白,参与胞吞、胞吐、细胞增殖、膜结构域的形成、囊泡的贩运等多种细胞过程。近年来研究表明,AnxA2蛋白通过与病毒蛋白的相互作用参与病毒的整个生命周期,包括吸附和侵入、复制、组装和释放等过程,进而影响病毒的整个复制周期。本文主要从AnxA2的定位和功能方面概述了其参与病毒复制周期的作用。

Annexin A2(AnxA2)is a calcium-dependent phospholipid-binding protein,which participates in many cellular processes,such as endocytosis,exocytosis,cell proliferation,formation of membrane domains and vesicle trafficking.Recent studies have shown that AnxA2 protein participates in the whole life cycle of viruses by interacting with viral proteins,including adhesion and invasion,replication and assembly and release,and then affect the entire replication cycle of the virus.In this paper,the role of AnxA2 is summarized in terms of its location and function in the replication cycle of viruses.