犬瘟热病毒受体研究进展

Progress on Receptors of Canine Distemper Virus

犬瘟热(CD)是由犬瘟热病毒(CDV)感染引起的一种传染病。CDV可感染多种动物,并且给犬业和其他毛皮动物产业造成巨大的经济损失。CDV的受体是与CD发病机制密切相关,主要是SLAM(信号淋巴细胞活化分子)和PVRL4(脊髓灰质炎病毒受体样蛋白4,又称连接蛋白4)。除了这两种受体外,CDV还可能通过其他受体感染动物。本文就CDV感染受体的研究进展进行总结,以期更好地了解CDV的发病机制。

Canine distemper(CD)is an infectious disease caused by canine distemper virus(CDV).CDV can infect many species of animals and cause huge economic losses in canine and other fur animal industry.The major CDV receptors are the signaling lymphocyte activation molecule(SLAM)and the poliovirus receptor-like protein-4(PVRL4,also known as Nectin-4),which are closely related to the pathogenesis of CD.In addition to these two distinct receptors,CDV may also infect animals through other unknown receptors.This article reviews advances in the knowledge on CDV cell receptors to get a better understanding of the pathogenesis of CDV.