生物碱类天然药物治疗类风湿性关节炎作用机制研究进展

Treatment of Rheumatoid Arthritis with Alkaloids in Natural Medicines:A Review

类风湿性关节炎(rheumatoid arthritis,RA)是一种病因未明的以慢性多关节滑膜炎为主要特征的系统性疾病。目前,临床上尚无治疗RA的理想药物,现有药物存在不良反应大或疗效不佳等问题。因此,寻找高效低毒的治疗药物仍是抗RA研究的迫切任务。天然药物治疗RA历史悠久、疗效确切且不良反应较小,近年来国内外学者对天然药物抗RA作用进行了大量的实验性研究,并在作用机制方面取得了较大进展,其中生物碱类抗RA天然药物具有一定的代表性。系统综述了RA的发病机制及典型生物碱类天然药物抗RA的作用机制,以期为有效治疗RA的创新药物研发提供有益参考。

Rheumatoid arthritis(RA)is a systemic disease characterized by chronic polyarticular synovitis,the etiology of which remains unclear.Nowadays,there is no clinically ideal drug for the treatment of RA.Regarding current drugs,patients suffer from serious side effects,unsatisfactory efficacy,etc.Searching for effective and low-toxicity therapeutic drugs,therefore,is still an urgent task for anti-RA research.Natural medicines have definite curative effects and less toxic and side effects with a long history in the treatment of RA.In recent years,scientists have carried out a large number of experiments on the anti-RA effects of natural medicines and have made great progress in their mechanism of action,among which the anti-RA natural medicines based on alkaloids are outstanding.The pathogenesis of RA and the mechanism of action of these typical natural medicines against RA are systematically reviewed.This study provides useful references for the development of innovative drugs effective in treating RA.