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脂肪变性供肝缺血再灌注损伤的机制研究进展

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摘要 缺血再灌注损伤会影响肝移植术后肝功能恢复,脂肪供肝则会加重上述情况。本文从细胞和分子角度分析了脂肪肝缺血再灌注损伤的发生机制,包括线粒体功能障碍,内质网应激和自噬的启动,泛素-蛋白酶体系统的失衡及各种效应分子等,为减少并预防肝脏移植术后缺血再灌注损伤的发生提供新的研究思路。
出处 《中华器官移植杂志》 CAS 2022年第4期242-246,共5页 Chinese Journal of Organ Transplantation
基金 湖北陈孝平科技发展基金会肿瘤防治研究槐耳专项基金(CXPJJH11900002-058)。
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