克林霉素联合复方磺胺甲噁唑分散片治疗艾滋病伴肺孢子菌肺炎患者的效果

Effects of Clindamycin combined with compound sulfamethoxazole dispersible tablets in treatment of AIDS patients with pneumocystis pneumonia

目的:观察克林霉素联合复方磺胺甲噁唑分散片治疗艾滋病伴肺孢子菌肺炎患者的效果。方法:选取104例艾滋病伴肺孢子菌肺炎患者为研究对象,按简单随机化法分为对照组(52例,口服复方磺胺甲噁唑分散片治疗)与观察组(52例,采用克林霉素联合复方磺胺甲噁唑分散片治疗)。比较两组临床疗效、治疗前后实验室指标[白蛋白(ALB)、乳酸脱氢酶(LDH)]水平、血气指标[动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))]水平,以及不良反应发生情况。结果:观察组治疗总有效率为96.15%(50/52),高于对照组的82.69%(43/52),差异有统计学意义(P<0.05);治疗后,两组ALB水平均高于治疗前,且观察组高于对照组,两组LDH水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组PaO_(2)、SaO_(2)水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:克林霉素联合复方磺胺甲噁唑分散片治疗艾滋病伴肺孢子菌肺炎患者可提高治疗总有效率和血气指标水平,改善实验室指标水平,效果优于单纯复方磺胺甲噁唑分散片治疗。

Objective:To observe effects of Clindamycin combined with compound sulfamethoxazole dispersible tablets in treatment of AIDS patients with pneumocystis pneumonia.Methods:104 AIDS patients with pneumocystis pneumonia were selected as the research objects and were divided into control group(52 cases,treated with oral compound sulfamethoxazole dispersible tablets)and observation group(52 cases,treated with Clindamycin combined with compound sulfamethoxazole dispersible tablets)according to the simple randomization method.The clinical effects,the laboratory indicator levels[albumin(ALB),lactate dehydrogenase(LDH)],the blood gas indicator levels[arterial partial pressure of oxygen(PaO_(2)),blood oxygen saturation(SaO_(2))]levels,and the adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 96.15%(50/52),which was higher than 82.69%(43/52)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the ALB levels in the two groups were higher than before the treatment,and that of observation group was higher than that of the control group;the LDH levels in the two groups were lower than before the treatment,and that of the observation group was lower than that of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of PaO_(2)and SaO_(2)in the two groups were higher than those before the treatment;those of the observation group was higher than those of the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Clindamycin combined with compound sulfamethoxazole dispersible tablets in the treatment of the AIDS patients with pneumocystis pneumonia can improve the total effective rate of treatment,the blood gas indicator levels,and the laboratory indicator levels.Moreover,it is superior to single compound sulfamethoxazole dispersible tablets.