肥胖对子代常见先天性畸形的影响及可能机制的研究进展

Progress on association of obesity with common congenital heart diseases and its underlying mechanisms

孕前肥胖会增加子代先天性畸形, 包括神经系统畸形、先天性心脏病、先天性肾脏和泌尿系统异常、唇腭裂、肛门直肠闭锁等的发生风险。这可能与肥胖机体存在的高胰岛素抵抗、慢性炎症状态以及高氧化应激反应等代谢异常, 以及肥胖孕妇营养素如叶酸的相对缺乏等有关。因此, 建议肥胖女性计划妊娠, 注意微量元素如叶酸等的补充, 将自身健康调整到最佳状态后再妊娠。

Maternal obesity is associated with an increased risk of a range of congenital malformations in offspring,including neurological malformations,congenital heart disease,congenital kidney and urinary system abnormalities,cleft lip and palate,anorectal atresia,etc.This may be related to existing metabolic abnormalities,including increased insulin resistance,chronic inflammation,and oxidative stress caused by excessive accumulation of fat,as well as the relative deficiency of nutrients such as folic acid in obese pregnant women.Therefore,it is recommended that obese women have a planned pregnancy,address folate and micronutrient supplementation and optimize their health status prior to conception.