备孕期、妊娠期和哺乳期过敏原免疫治疗的研究进展

Progress on allergen immunotherapy during pre-pregnancy,pregnancy,and lactation periods

过敏原免疫治疗(allergen immunotherapy,AIT),又称过敏原疫苗脱敏治疗,是唯一能够改变过敏性疾病自然进程的治疗方法。妊娠期女性AIT是新生儿过敏的保护因素。现有证据显示,不推荐在备孕期、妊娠期、哺乳期开始AIT;AIT期间意外妊娠,无需终止妊娠;AIT对胎儿和婴幼儿无明显不良影响;备孕期、妊娠期、哺乳期可继续维持量AIT。

Allergen immunotherapy(AIT),also known as allergen vaccine desensitization,is currently the only treatment that can change the natural course of allergic diseases.AIT for pregnant women is a protective factor for neonatal allergies.Existing findings suggest that AIT should not be started during pre-pregnancy,pregnancy,or lactation periods,but can be continued if has already been started before;unexpected pregnancy during AIT does not require termination;AIT shows no obvious adverse effects on fetuses,infants,and young children.The latest evidence on the effectiveness and safety of AIT during pre-pregnancy,pregnancy,and lactation periods were reviewed.