血清hs-CRP水平与青少年首发抑郁症的相关性研究

Correlation study of serum hs-CRP and the first-episode depression in adolescents

目的:探讨青少年首发抑郁症患者在治疗前后其血清超敏C反应蛋白(hs-CRP)水平的变化及其与病情严重程度的相关性。方法:纳入60例青少年首发抑郁症患者(病例组)、60例健康青少年(对照组),病例组应用盐酸舍曲林治疗6周,测量病例组基线及治疗后1、2、4、6周末和对照组入组时的血清hs-CRP水平,应用汉密尔顿抑郁量表(HAMD-24)评定被试的抑郁症状严重程度。结果:病例组在治疗前及治疗后第1、2、4、6周末的HAMD-24评分总分和血清hs-CRP水平均显著高于对照组(P<0.01)。相关分析显示,病例组患者在治疗前及治疗后第1、2、4、6周末的血清hs-CRP水平与HAMD-24评分呈正相关(P<0.01)。结论:青少年首发抑郁症患者的血清hs-CRP水平显著高于对照组,血清hs-CRP水平能够反映青少年首发抑郁症患者的病情严重程度。

Objective:To investigate the changes of hypersensitive C-reactive protein(hs-CRP)level of adolescents with first-episode depression before and after treatment and its correlation with the severity of the disease.Methods:60 adolescents with first-episode depression were included as case group who were given sertraline hydrochloride for 6 weeks of clinical treatment,and 60 healthy adolescents of the same age were selected as control group.Serum hs-CRP levels were measured at baseline and at the end of 1,2,4 and 6 weeks after treatment,and at the time of enrollment in the control group.The Hamilton Depression Scale(HAMD-24)was used to assess the mood and the severity and condition changes of the two groups.Results:The total scores of the HAMD-24 and the serum hs-CRP levels of the case group measured before treatment and the first,second,fourth,and sixth week after treatment were significantly higher than those of the healthy control group(P<0.01).Correlation analysis showed that the serum hs-CRP levels of the adolescents with first-episode depression before treatment and the first,second,fourth,and sixth weekend after treatment were positively correlated with the total score of HAMD-24(P<0.01).There was a positive correlation between the level of serum hs-CRP in the case group before treatment and total score of HAMD-24.Conclusion:Serum hs-CRP levels are significantly higher in adolescent first-episode depression patients compared with the control group,and serum hs-CRP levels could reflect the severity of the condition in adolescent first-episode depression patients.